大鼠发育过程中血浆和肝脏中T-激肽原水平的变化。

Changes of T-kininogen levels in plasma and liver during development of rats.

作者信息

Hayashi I, Kusunoki A, Nagashima Y, Hayashi M, Oh-ishi S

机构信息

Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

出版信息

Adv Exp Med Biol. 1989;247B:283-6. doi: 10.1007/978-1-4615-9546-5_47.

DOI:10.1007/978-1-4615-9546-5_47

PMID:2610074

Abstract

T-kininogen levels of plasma and liver were measured in rats during development by RIA. We found that higher levels of T-kininogen in plasma and liver of neonates and of the mother rats at around term. The plasma level of mature male rats was as low as 1/5 to 1/2 of that of mature female rats. T-kininogen levels in male and female rats increased after treatment with estradiol, indicating that sex hormones may regulate the physiological level of T-kininogen in rats.

摘要

通过放射免疫分析法（RIA）测定了发育过程中大鼠血浆和肝脏中的T -激肽原水平。我们发现，新生大鼠以及接近足月的母鼠血浆和肝脏中的T -激肽原水平较高。成熟雄性大鼠的血浆水平低至成熟雌性大鼠的1/5至1/2。用雌二醇处理后，雄性和雌性大鼠的T -激肽原水平均升高，表明性激素可能调节大鼠体内T -激肽原的生理水平。