Bouhnik J, Savoie F, Michaud A, Baussant T, Alhenc-Gelas F, Corvol P
INSERM U36, Pathologie Vasculaire et Endocrinologie Rénale, Paris, France.
Life Sci. 1989;44(24):1859-66. doi: 10.1016/0024-3205(89)90303-2.
The influence of sex hormones on rat plasma T-kininogen concentration was examined. The level of T-kininogen in the post-pubertal female rat is about 3-times that of the male animal. Female rats castrated as adults or 15 days after birth, had low T-kininogen concentrations, near those of male rats. In contrast, castration of mature or immature male animals induced no change in T-kininogen. Treatment of castrated female or male rats with 17 alpha-ethinylestradiol significantly increased the T-kininogen level, whereas administration of testosterone or progesterone had no effect. The influence of estrogen was specific for T-kininogen, since plasma HMW kininogen concentration was the same in male and female rats and was not affected by castration or sex hormone treatment. T-kininogen concentration was not significantly changed in pregnant rat between the 12th and the 20th day of pregnancy, but increased after parturition. It was high in the newborn rat at birth and then decreased similarly over the next 3 weeks in males and females. It continued to decrease in the males, reaching the level of the adult rat, but it increased in the female from 3-4 weeks of age and reached the adult level at about 6-8 weeks. These data indicate that natural estrogens have a physiological influence on the plasma level of T-kininogen in female rats whereas testosterone had no effect on either male or castrated female rats. HMW kininogen is not physiologically dependent on sex hormones.
研究了性激素对大鼠血浆T -激肽原浓度的影响。青春期后雌性大鼠的T -激肽原水平约为雄性动物的3倍。成年后或出生后15天阉割的雌性大鼠，其T -激肽原浓度较低，接近雄性大鼠。相反，对成熟或未成熟雄性动物进行阉割，T -激肽原无变化。用17α -乙炔雌二醇治疗去势的雌性或雄性大鼠，可显著提高T -激肽原水平，而给予睾酮或孕酮则无作用。雌激素的影响对T -激肽原具有特异性，因为雄性和雌性大鼠血浆高分子量激肽原浓度相同，且不受阉割或性激素治疗的影响。怀孕大鼠在妊娠第12天至第20天期间，T -激肽原浓度无显著变化，但产后升高。新生大鼠出生时T -激肽原浓度较高，随后在接下来的3周内，雄性和雌性大鼠均类似地下降。雄性大鼠继续下降，达到成年大鼠水平，而雌性大鼠从3 - 4周龄开始升高，约在6 - 8周龄时达到成年水平。这些数据表明，天然雌激素对雌性大鼠血浆T -激肽原水平具有生理影响，而睾酮对雄性或去势雌性大鼠均无作用。高分子量激肽原在生理上不依赖于性激素。
