Balderia Percy Guanzon, Chandorkar Aditya, Kim Yongwoo, Patnaik Soumya, Sloan Joshua, Newman George Charles
From the Department of Medicine, and.
†Department of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, Pennsylvania.
J Patient Saf. 2018 Jun;14(2):e33-e34. doi: 10.1097/PTS.0000000000000225.
Dosing cefepime for renal function does not completely prevent neurotoxicity in a kidney transplant patient. Cefepime neurotoxicity has been reported primarily among patients with renal insufficiency who received standard doses of the antibiotic. We report a case of nonconvulsive status epilepticus from dose-adjusted cefepime in a kidney transplant patient. The timing of symptoms along with clinical and electroencephalographic improvement after discontinuation of cefepime was critical to the diagnosis. Whether we should adjust the dose of cefepime differently in a patient with transplanted kidney to prevent neurotoxicity is unknown.
根据肾功能调整头孢吡肟剂量并不能完全预防肾移植患者出现神经毒性。头孢吡肟神经毒性主要在接受标准剂量该抗生素的肾功能不全患者中被报道。我们报告了一例肾移植患者因剂量调整的头孢吡肟导致非惊厥性癫痫持续状态的病例。症状出现的时间以及停用头孢吡肟后临床和脑电图的改善情况对诊断至关重要。对于肾移植患者，是否应不同地调整头孢吡肟剂量以预防神经毒性尚不清楚。
