头孢吡肟过量导致的肌阵挛性癫痫持续状态，需进行血液透析。
Myoclonic status epilepticus induced by cefepime overdose requiring haemodialysis.
作者信息
Garin Aude, Bavozet Florent
机构信息
Department of Intensive Care, Centre Hospitalier Victor Jousselin, Dreux, France.
出版信息
BMJ Case Rep. 2019 Jun 6;12(6):e228108. doi: 10.1136/bcr-2018-228108.
Abstract
We report a case of cefepime neurotoxicity characterised by myoclonic status epilepticus with coma, in a context of acute renal failure and requiring one discontinuous conventional haemodialysis. Cefepime is a fourth-generation broad-spectrum cephalosporin mainly used to treat hospital-acquired Gram-negative infections. Acute neurotoxicity is an increasingly reported adverse effect which occurs predominantly in patients with renal impairment. Renal replacement therapy has been proposed to treat this condition.
摘要
我们报告了一例头孢吡肟神经毒性病例，其特征为伴有昏迷的肌阵挛性癫痫持续状态，发生在急性肾衰竭的背景下，且需要进行一次非连续性常规血液透析。头孢吡肟是一种第四代广谱头孢菌素，主要用于治疗医院获得性革兰氏阴性菌感染。急性神经毒性是一种报告日益增多的不良反应，主要发生在肾功能损害患者中。已提出采用肾脏替代疗法来治疗这种情况。
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