Department of Pharmacology, PSG College of Pharmacy, Coimbatore 641004, Tamil Nadu, India.
Department of Pharmacology, PSG College of Pharmacy, Coimbatore 641004, Tamil Nadu, India.
Chem Biol Interact. 2015 Aug 5;238:118-28. doi: 10.1016/j.cbi.2015.06.025. Epub 2015 Jun 20.
Hyperalgesia, allodynia, delayed motor nerve conduction velocity, oxidative stress and axonal damage are signs and symptoms of chemotherapy induced peripheral neuropathy (CIPN). Present treatment/preventive strategies of CIPN are futile and the neuropathy may even lead to discontinuation of chemotherapy. In this study, we evaluated the protective effect of tetrahydrocurcumin (THC) 40 and 80mg/kg in experimental vincristine induced neuropathy in rats. Hyperalgesia was assessed by hot plate (thermal), Randall-Selitto (mechanical) test, allodynia was assessed by cold plate (thermal) test, functional loss was measured by sciatic function index, nociception was evaluated by formalin test. Neurophysiological recordings were carried out to assess motor nerve conduction velocity. Total calcium levels, oxidative stress and TNF-α was measured in sciatic nerve tissue homogenate to assess neuropathy. Histopathological changes was observed on sciatic nerve to assess the protective effect of THC against the vincristine. Pregabalin was used as a standard in this study. Rats administered with THC at 80mg/kg significantly attenuated the vincristine induced neuropathic pain manifestations which may be due to its multiple actions including anti-nociceptive, anti-inflammatory, neuroprotective, calcium inhibitory and antioxidant effect. This study delineates that THC can be a promising candidate for the prevention of CIPN by chemotherapeutic agents.
痛觉过敏、感觉异常、运动神经传导速度延迟、氧化应激和轴突损伤是化疗引起的周围神经病变（CIPN）的症状和体征。目前针对 CIPN 的治疗/预防策略均无效，且神经病变甚至可能导致化疗中断。在这项研究中，我们评估了四氢姜黄素（THC）40 和 80mg/kg 对实验性长春新碱诱导的大鼠周围神经病变的保护作用。通过热板（热）、兰德尔-塞利托（机械）试验评估痛觉过敏，通过冷板（热）试验评估感觉异常，通过坐骨神经功能指数测量功能丧失，通过福尔马林试验评估痛觉。进行神经生理记录以评估运动神经传导速度。测量坐骨神经组织匀浆中的总钙水平、氧化应激和 TNF-α，以评估神经病变。观察坐骨神经的组织病理学变化，以评估 THC 对长春新碱的保护作用。在这项研究中，普瑞巴林被用作标准。给予 THC 80mg/kg 的大鼠显著减轻了长春新碱引起的神经性疼痛表现，这可能是由于其多种作用，包括抗伤害感受、抗炎、神经保护、钙抑制和抗氧化作用。这项研究表明，THC 可能是预防化疗药物引起的 CIPN 的有前途的候选药物。
