铜/银介导的 2-噻吩甲酸 C(sp(2))-H 芳基化反应。
Copper-/Silver-Mediated Arylation of C(sp(2))-H Bonds with 2-Thiophenecarboxylic Acids.
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
出版信息
Org Lett. 2015 Jul 2;17(13):3338-41. doi: 10.1021/acs.orglett.5b01560. Epub 2015 Jun 23.
PMID:26102510
Abstract
A copper/silver-mediated arylation of (hetero)aryl C-H bonds with 2-thiophenecarboxylic acids has been achieved. The protocol features a broad substrate scope and high functional group tolerance. Preliminary mechanistic studies indicate that a cascade protodecarboxylation/dehydrogenative coupling process is likely involved.
摘要
铜/银介导的（杂）芳基 C-H 键与 2-噻吩羧酸的芳基化反应已经实现。该方案具有广泛的底物范围和高官能团容忍度。初步的机理研究表明，可能涉及级联脱羧/脱氢偶联过程。
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