Ohyama Tomoya, Uchida Masako, Kusama Hiroyuki, Iwasawa Nobuharu
Department of Chemistry, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.
Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo, 171-8588, Japan.
Chem Asian J. 2015 Sep;10(9):1850-3. doi: 10.1002/asia.201500491. Epub 2015 Jul 14.
Total synthesis of the proposed structure of yuremamine has been achieved for the first time based on the intermolecular [3+2]-cycloaddition reaction of the platinum-containing azomethine ylide. All the possible diastereomers of yuremamine were also synthesized via the common intermediate. Through these syntheses, it was confirmed that the proposed structure of yuremamine and the diastereomers differ from the natural product.
基于含铂甲亚胺叶立德的分子间[3+2]环加成反应，首次实现了对育亨胺假定结构的全合成。育亨胺所有可能的非对映异构体也通过共同中间体合成。通过这些合成，证实了育亨胺的假定结构及其非对映异构体与天然产物不同。
