Cheng Kang
Laboratory for Cognitive Brain Mapping and Support Unit for Functional Magnetic Resonance Imaging, RIKEN Brain Science Institute.
Magn Reson Med Sci. 2016;15(1):1-10. doi: 10.2463/mrms.2015-0008. Epub 2015 Jun 23.
This article reviews our exploration of structures and functions of the human visual cortex using high resolution (submillimeter) functional magnetic resonance imaging (fMRI). It discusses factors that restrict the spatial resolution of blood oxygenation-level dependent (BOLD) fMRI-the point-spread function of the BOLD signal, limited by both imaging techniques to be used and neurovascular units to be studied, and the signal-to-noise ratio. I offer personal thoughts regarding optimal solutions for dealing with these issues, summarize techniques we have developed over the years for using high resolution fMRI to visualize functional architectures and explore physiological properties in the primary visual cortex of humans, including choices of imaging hardware and pulse sequences, experimental procedures, and stimulation paradigms, and finally offer my personal opinions regarding the future of high resolution fMRI.
本文回顾了我们使用高分辨率（亚毫米级）功能磁共振成像（fMRI）对人类视觉皮层的结构和功能进行的探索。它讨论了限制血氧水平依赖（BOLD）功能磁共振成像空间分辨率的因素——BOLD信号的点扩散函数，这受到要使用的成像技术和要研究的神经血管单元以及信噪比的限制。我就处理这些问题的最佳解决方案提出了个人想法，总结了我们多年来开发的使用高分辨率功能磁共振成像来可视化功能结构并探索人类初级视觉皮层生理特性的技术，包括成像硬件和脉冲序列的选择、实验程序以及刺激范式，最后就高分辨率功能磁共振成像的未来提出了我的个人观点。
