Hu Xiaohan, Frellesen Claudia, Kerl J Matthias, Bauer Ralf W, Beeres Martin, Bodelle Boris, Lehnert Thomas, Vogl Thomas J, Wichmann Julian L
University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Eur J Radiol. 2015 Oct;84(10):1910-4. doi: 10.1016/j.ejrad.2015.06.003. Epub 2015 Jun 6.
To investigate the association between aortic root calcification (ARC) and coronary artery calcification (CAC) assessed by coronary artery calcium-scoring dual-source computed tomography (DSCT).
We retrospectively analyzed 143 consecutive patients who underwent coronary artery calcium-scoring during coronary DSCT angiography. 57 patients had findings of ARC on calcium-scoring scans. ARC volume (ARCV) and Agatston coronary artery calcium score (CACS) were calculated. Chi-square test was used to assess differences of categorical variables between patients with and without ARC. Statistical significances between both groups were assessed with the independent-Sample t test.
Compared with patients without ARC (n=86), patients with ARC (n=57) showed a significantly higher presence of CAC (87.7% vs. 24.4%; P<0.001), and a higher mean CACS (700.6 ± 941.2 vs. 256.4 ± 724.3; P=0.009) in patients with CAC. Patients with a calculated ARCV > 40 mm(3) (n=32) showed significantly higher rates of severe CAC (56.3% vs. 24.0%; P=0.014) compared with patients with an ARCV< 40 mm(3) (n=25). Compared with patients without CAC (n=42), patients with CAC (n=101) showed a significantly higher presence of ARC (83.3% vs. 50.5%; P<0.001) and a higher mean ARCV (95.4 ± 116.2mm(3) vs. 29.7 ± 33.0 mm(3); P=0.003). Severe CAC (n=24) correlated with an increased mean ARCV (122.3 ± 148.8mm(3)) compared to patients with minimal to moderate CAC (n=33, mean ARCV: 61.9 ± 64.8mm(3); P<0.05).
The extent of ARC is directly associated with the presence and degree of CAC on calcium-scoring scans during coronary DSCT angiography.
通过冠状动脉钙化积分双源计算机断层扫描（DSCT）研究主动脉根部钙化（ARC）与冠状动脉钙化（CAC）之间的关联。
我们回顾性分析了143例在冠状动脉DSCT血管造影期间接受冠状动脉钙化积分检查的连续患者。57例患者在钙化积分扫描中有ARC表现。计算ARC体积（ARCV）和阿加斯顿冠状动脉钙化积分（CACS）。采用卡方检验评估有ARC和无ARC患者分类变量的差异。两组间的统计学显著性采用独立样本t检验进行评估。
与无ARC的患者（n = 86）相比，有ARC的患者（n = 57）显示CAC的存在率显著更高（87.7%对24.4%；P < 0.001），且有CAC的患者平均CACS更高（700.6±941.2对256.4±724.3；P = 0.009）。计算得出ARCV>40 mm³的患者（n = 32）与ARCV<40 mm³的患者（n = 25）相比，严重CAC的发生率显著更高（56.3%对24.0%；P = 0.014）。与无CAC的患者（n = 42）相比，有CAC的患者（n = 101）显示ARC的存在率显著更高（83.3%对50.5%；P < 0.001）且平均ARCV更高（95.4±116.2mm³对29.7±33.0 mm³；P = 0.003）。与轻度至中度CAC的患者（n = 33，平均ARCV：61.9±64.8mm³）相比，严重CAC（n = 24）与平均ARCV增加（122.3±148.8mm³）相关（P < 0.05）。
在冠状动脉DSCT血管造影期间的钙化积分扫描中，ARC的程度与CAC的存在及程度直接相关。
