Koff Jean L, Chihara Dai, Phan Anh, Nastoupil Loretta J, Williams Jessica N, Flowers Christopher R
Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Rd NE, Building B, Suite 4302, Atlanta, GA, USA,
Curr Hematol Malig Rep. 2015 Sep;10(3):244-55. doi: 10.1007/s11899-015-0267-0.
Non-Hodgkin lymphoma (NHL) constitutes a diverse group of more than 40 subtypes, each characterized by distinct biologic and clinical features. Until recently, pinpointing genetic and epidemiologic risk factors for individual subtypes has been limited by the relative rarity of each. However, several large pooled case-control studies have provided sufficient statistical power for detecting etiologic differences and commonalities between subtypes and thus yield new insight into their unique epidemiologic backgrounds. Here, we review the subtype-specific medical, lifestyle, and biologic components identified in these studies, which suggest that a complex interplay between host genetics, autoimmune disorders, modifiable risk factors, and occupation contributes to lymphomagenesis.
非霍奇金淋巴瘤（NHL）由40多种不同亚型组成，每种亚型都具有独特的生物学和临床特征。直到最近，由于每种亚型相对罕见，确定个体亚型的遗传和流行病学风险因素一直受到限制。然而，几项大型汇总病例对照研究提供了足够的统计效力来检测亚型之间的病因差异和共性，从而对其独特的流行病学背景有了新的认识。在此，我们回顾了这些研究中确定的亚型特异性医学、生活方式和生物学因素，这些因素表明宿主遗传学、自身免疫性疾病、可改变的风险因素和职业之间的复杂相互作用促成了淋巴瘤的发生。
