Laskowska Marzena, Laskowska Katarzyna, Oleszczuk Jan
Department of Obstetrics and Perinatology, Medical University of Lublin, 20-950 Lublin, ul. Jaczewskiego 8, Poland.
Department of Gastroenterology, 20-950 Lublin, ul. Jaczewskiego 8, Poland.
Pregnancy Hypertens. 2012 Apr;2(2):168-73. doi: 10.1016/j.preghy.2012.01.008. Epub 2012 Feb 19.
The aim of this study was to investigate the maternal serum of soluble human leukocyte antigen-G (sHLA-G) levels in pregnant women with an isolated intrauterine growth restricted foetus (IUGR) and in preeclamptic pregnancies with and without IUGR.
The study was conducted on 31 normotensive patients with pregnancy complicated by IUGR, 17 preeclamptic patients with appropriate-for-gestational-age foetal intrauterine growth, 21 with preeclampsia complicated by IUGR, and 32 healthy pregnant controls. Maternal serum sHLA-G levels were calculated using the enzyme-linked immunosorbent assay.
Maternal serum sHLA-G levels tended to be higher in both groups of preeclamptic patients, and were highest in patients with IUGR in the course of severe preeclampsia. Lower serum levels of sHLA-G were observed in the group of normotensive pregnant women with an intrauterine growth restricted foetus, but these differences were not statistically significant. The mean values were 22.759±14.151units/mL in the IUGR group, 25.948±18.888units/mL in preeclamptic patients with normal intrauterine foetal growth, 31.646±27.576units/mL in preeclamptic pregnant women with IUGR, and 24.178±24.828units/mL in the healthy controls.
Our findings suggest that the increased levels of sHLA-G in the maternal serum may play a significant role in the pathogenesis of preeclampsia, especially in preeclampsia complicated by intrauterine foetal growth restriction. These associations may offer a better insight into the etiology and pathogenesis of preeclampsia with and without IUGR. It seems that sHLA-G does not play a clinically significant role in the pathogenesis of isolated intrauterine foetal growth restriction in normotensive pregnancies.
本研究旨在调查单纯性胎儿宫内生长受限（IUGR）孕妇以及伴或不伴IUGR的子痫前期孕妇血清中可溶性人类白细胞抗原-G（sHLA-G）水平。
本研究纳入31例血压正常且合并IUGR的孕妇、17例胎儿宫内生长符合孕周的子痫前期患者、21例合并IUGR的子痫前期患者以及32例健康孕妇作为对照。采用酶联免疫吸附测定法计算孕妇血清sHLA-G水平。
两组子痫前期患者的孕妇血清sHLA-G水平均有升高趋势，在重度子痫前期合并IUGR的患者中最高。血压正常但胎儿宫内生长受限的孕妇组sHLA-G血清水平较低，但这些差异无统计学意义。IUGR组的平均值为22.759±14.151单位/毫升，胎儿宫内生长正常的子痫前期患者为25.948±18.888单位/毫升，合并IUGR的子痫前期孕妇为31.646±27.576单位/毫升，健康对照组为24.178±24.828单位/毫升。
我们的研究结果表明，孕妇血清中sHLA-G水平升高可能在子痫前期发病机制中起重要作用，尤其是在合并胎儿宫内生长受限的子痫前期中。这些关联可能有助于更好地理解伴或不伴IUGR的子痫前期的病因和发病机制。似乎sHLA-G在血压正常的妊娠中单纯性胎儿宫内生长受限的发病机制中不发挥临床显著作用。
