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伐尼克兰治疗后出现的撤药后运动障碍

Withdrawal-Emergent Dyskinesias following Varenicline Therapy.

作者信息

Toffey Brittany A, Rabin Marcie, Kurlan Roger

机构信息

Atlantic Neuroscience Institute, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07901, USA.

出版信息

Open Neurol J. 2015 May 29;9:7-8. doi: 10.2174/1874205X01509010007. eCollection 2015.

Abstract

Varenicline (Chantix[R]) is a nicotinic acetylcholine receptor partial agonist used to aid smoking cessation. Adverse psychiatric and behavioral effects of the drug are recognized and national drug monitoring has included reports of tardive dyskinesia, but no cases have been described in the literature. We now report the first two cases of varenicline-related withdrawal emergent dyskinesias.

摘要

伐尼克兰(畅沛[R])是一种用于辅助戒烟的烟碱型乙酰胆碱受体部分激动剂。该药物的不良精神和行为影响已得到认可,国家药物监测已包括迟发性运动障碍的报告,但文献中尚未描述过相关病例。我们现在报告首例两例与伐尼克兰相关的戒断后突发运动障碍病例。

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引用本文的文献

1
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Clin Psychopharmacol Neurosci. 2021 May 31;19(2):355-360. doi: 10.9758/cpn.2021.19.2.355.
2
Possible varenicline withdrawal-induced akathisia: A case report.
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本文引用的文献

2
Does the degree of smoking effect the severity of tardive dyskinesia? A longitudinal clinical trial.
Eur Psychiatry. 2009 Jan;24(1):33-40. doi: 10.1016/j.eurpsy.2008.07.007. Epub 2008 Sep 6.
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Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid.
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Nicotine exposure and tardive dyskinesia.
Biol Psychiatry. 1987 Jan;22(1):67-72. doi: 10.1016/0006-3223(87)90131-4.

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