Mohamadkhani Ashraf, Poustchi Hossein
Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Middle East J Dig Dis. 2015 Apr;7(2):61-8.
Human biorepositories are collection of biological samples and health information from a large number of participants generally in the cohort studies. The main purpose of established biobanks is organization of biomedical research for upgrading the knowledge of human disorders from cancer to infectious and rare disease. The studies of generation relationships and understanding the preclinical stages of ageing are also from the solution of bitobank. This review overview the significance and storage condition of biospecimens including whole blood, red blood cells (RBC), buffy coat, plasma, serum, DNA and RNA that derived from blood in human biobanks. These biological samples provide valuable information on the prevalence of germline mutations, epigenetic modifications or interaction between genes and proteins in associated with the development of certain types of disease. The quality of biospecimen in biobanks is a powerful tool for valid identification of biomarkers. Therefore optimum qualities of human biological samples in long time storage that have been assessed in several studies also indicate in this review.
人类生物样本库是从大量参与者（通常是在队列研究中）收集的生物样本和健康信息。已建立的生物样本库的主要目的是组织生物医学研究，以提升对从癌症到传染病和罕见病等人类疾病的认识。对代际关系的研究以及对衰老临床前阶段的理解也来自生物样本库的解决方案。本综述概述了人类生物样本库中源自血液的生物样本（包括全血、红细胞（RBC）、血沉棕黄层、血浆、血清、DNA和RNA）的意义和储存条件。这些生物样本提供了有关种系突变、表观遗传修饰或与某些类型疾病发展相关的基因与蛋白质之间相互作用的流行情况的宝贵信息。生物样本库中生物样本的质量是有效鉴定生物标志物的有力工具。因此，本综述也指出了在多项研究中评估过的人类生物样本长时间储存的最佳质量。
