Mansour-Ghanaei Fariborz, Haghkerdar Maryam, Joukar Farahnaz, Aminian Keyvan, Yousefi Mashhour Mahmoud, Shafaghi Afshin, Fakhriyeh Asl Saba, Ghanavi Zahra
Professor, Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran.
Researcher, Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran.
Middle East J Dig Dis. 2015 Apr;7(2):69-74.
BACKGROUND The geographical incidence of IBD varies considerably. This study aimed to survey the epidemiologic features of IBD in Guilan province, North of Iran, during ten years duration. METHODS In this retrospective cross-sectional study, we assessed the documents of 868 patients with IBD referred to private and governmental clinics of Guilan province between 2002 and 2012. Variables such as demographic data, risk factors, diagnosis, extraintestinal manifestations and type of treatment were collected. RESULTS Among 868 patients with IBD, 756 patients (87.1%) diagnosed as UC and 112 patients (12.9%) as CD. The mean age of patients with UC and CD was 46.73±15.79 and 40.15±14.27 years respectively. Male/female ratio in UC and CD was 0.92:1 and 0.75:1 respectively. The most common age of disease initiation in UC was 40-59 years and in CD 20-39 years (p<0.001). Extraintestinal manifestations were seen in 25.4 percent of patients with IBD. Most of patients were treated with combination of two drugs: salicylates and azathioprine (p<0.04). The incidence of IBD gradually increased during the past 4 years in Guilan province. CONCLUSION This study showed that CD were presented significantly more common in younger patients than UC and totally the disease was slightly more common in female.
炎症性肠病（IBD）的地理发病率差异很大。本研究旨在调查伊朗北部吉兰省10年间IBD的流行病学特征。
在这项回顾性横断面研究中，我们评估了2002年至2012年间转诊至吉兰省私立和政府诊所的868例IBD患者的病历。收集了人口统计学数据、危险因素、诊断、肠外表现和治疗类型等变量。
在868例IBD患者中，756例（87.1%）诊断为溃疡性结肠炎（UC），112例（12.9%）诊断为克罗恩病（CD）。UC和CD患者的平均年龄分别为46.73±15.79岁和40.15±14.27岁。UC和CD的男/女比例分别为0.92:1和0.75:1。UC发病最常见的年龄为40 - 59岁，CD为20 - 39岁（p<0.001）。25.4%的IBD患者有肠外表现。大多数患者接受两种药物联合治疗：水杨酸类药物和硫唑嘌呤（p<0.04）。在过去4年中，吉兰省IBD的发病率逐渐上升。
本研究表明，CD在年轻患者中比UC更常见，总体上该病在女性中略更常见。
