Assistant Professor of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran.
Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
BMC Public Health. 2024 May 24;24(1):1395. doi: 10.1186/s12889-024-18816-z.
Inflammatory bowel disease (IBD) consists of two main types: Crohn's disease (CD) and ulcerative colitis (UC). The epidemiology of IBD patients has not been comprehensively studied in EMRO countries; therefore, we conducted this meta-analysis to study the epidemiology of this disease in these countries.
We searched four international databases, namely Scopus, Web of Knowledge (ISI), Medline/PubMed, and ProQuest, from inception up to the end of May 2023. The Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guideline was used to carry out this systematic review and meta-analysis investigation. Using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist, the quality of the selected papers was assessed.
Based on the results of this study, the incidence of UC in EMRO countries was 2.65 per 100,000 (95% CI: 1.39-3.90), and the incidence of CD was 1.16 per 100,000 (95% CI: 0.73-1.59). The most commonly involved intestinal segment in CD was the terminal ileum (44.7%, 95% CI: 34.7-55.2), followed by the ileum (29.8%, 95% CI: 22.2-38.6), and colon (18.7%, 95% CI: 10.8-30.4). However, in UC patients, extensive colitis was the most common finding (32.3%, 95% CI: 26.4-38.8), followed by proctosigmoiditis (27.9%, 95% CI: 21.1-35.8), left-sided colitis (27.4%, 95% CI: 22.7-32.7), and proctitis (22.6%, 95% CI: 17.5-28.5).
As a result, we were able to establish the traits of IBD patients in EMRO nations. UC patients had a higher incidence than CD patients. The most common regions of involvement in CD and UC patients, respectively, were the colon and pancolitis. Compared to UC patients, CD patients had a higher history of appendectomy.
炎症性肠病（IBD）包括两种主要类型：克罗恩病（CD）和溃疡性结肠炎（UC）。EMRO 国家的 IBD 患者流行病学尚未得到全面研究；因此，我们进行了这项荟萃分析，以研究这些国家的这种疾病的流行病学。
我们从四个国际数据库（Scopus、Web of Knowledge（ISI）、Medline/PubMed 和 ProQuest）进行了搜索，从成立到 2023 年 5 月底。使用循证医学和荟萃分析的首选报告项目（PRISMA）指南进行了这项系统评价和荟萃分析调查。使用 Joanna Briggs 研究所（JBI）的批判性评价清单评估了选定论文的质量。
根据这项研究的结果，EMRO 国家的 UC 发病率为每 100,000 人 2.65 例（95%CI：1.39-3.90），CD 的发病率为每 100,000 人 1.16 例（95%CI：0.73-1.59）。CD 中最常受累的肠段是末端回肠（44.7%，95%CI：34.7-55.2），其次是回肠（29.8%，95%CI：22.2-38.6）和结肠（18.7%，95%CI：10.8-30.4）。然而，在 UC 患者中，广泛性结肠炎是最常见的发现（32.3%，95%CI：26.4-38.8），其次是直肠乙状结肠炎（27.9%，95%CI：21.1-35.8），左侧结肠炎（27.4%，95%CI：22.7-32.7）和直肠炎（22.6%，95%CI：17.5-28.5）。
因此，我们能够确定 EMRO 国家 IBD 患者的特征。UC 患者的发病率高于 CD 患者。CD 和 UC 患者分别最常见受累的区域是结肠和全结肠炎。与 UC 患者相比，CD 患者有更高的阑尾切除术史。
