Salobrar-Garcia Elena, de Hoz Rosa, Rojas Blanca, Ramirez Ana I, Salazar Juan J, Yubero Raquel, Gil Pedro, Triviño Alberto, Ramirez José M
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, Madrid, Spain.
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, Madrid, Spain ; Facultad de Óptica, Universidad Complutense de Madrid, Madrid, Spain.
J Ophthalmol. 2015;2015:736949. doi: 10.1155/2015/736949. Epub 2015 May 27.
Purpose. To analyze in mild Alzheimer's disease (MAD) patients, GDS-4 (Reisberg Scale), whether or not some psychophysical tests (PTs) support OCT macular findings in the same group of MAD patients reported previously. Methods. Twenty-three MAD patients and 28 age-matched control subjects with mean Mini Mental State Examination of 23.3 and 28.2, respectively, with no ocular disease or systemic disorders affecting vision were included. Best-corrected visual acuity (VA), contrast sensitivity (CS) (3, 6, 12, and 18 cpds), color perception (CP), and perception digital test (PDT) were tested in one eye of each patient. Results. In comparison with the controls, MAD patients presented (i) a significant decrease in VA, PDT, and CS for all spatial frequencies analyzed, especially the higher ones, and (ii) a significant increase in unspecific errors on the blue axis (P < 0.05 in all instances). In MAD patients, a wide aROC curve was plotted in all PTs. Conclusions. In MAD, CS, VA, and the tritan axis in CP were impaired. The PTs with the greatest predictive value are the higher spatial frequencies in CS and tritan unspecific errors in CP. PT abnormalities are consistent with the structural findings reported in the same MAD patients using OCT.
目的。分析轻度阿尔茨海默病（MAD）患者的GDS-4（雷斯伯格量表），以及一些心理物理学测试（PTs）是否支持先前报道的同一组MAD患者的OCT黄斑检查结果。方法。纳入23例MAD患者和28例年龄匹配的对照受试者，他们的简易精神状态检查表平均得分分别为23.3和28.2，且无影响视力的眼部疾病或全身性疾病。对每位患者的一只眼睛进行最佳矫正视力（VA）、对比敏感度（CS）（3、6、12和18周/度）、颜色感知（CP）和数字感知测试（PDT）。结果。与对照组相比，MAD患者表现出：（i）所有分析空间频率下的VA、PDT和CS均显著降低，尤其是较高空间频率，以及（ii）蓝色轴上非特异性误差显著增加（所有情况下P<0.05）。在MAD患者中，所有PTs均绘制出较宽的aROC曲线。结论。在MAD中，CS、VA和CP中的蓝绿色轴受损。预测价值最大的PTs是CS中的较高空间频率和CP中的蓝绿色非特异性误差。PT异常与使用OCT在同一MAD患者中报告的结构发现一致。
