Gordon Brian A, Najmi Safa, Hsu Phillip, Roe Catherine M, Morris John C, Benzinger Tammie L S
Department of Radiology, Washington University in St. Louis, USA ; Department of Psychology, Washington University in St. Louis, USA ; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, USA.
Department of Neurology, Tabriz University of Medical Science, Iran.
Neuroimage Clin. 2015 Apr 30;8:246-52. doi: 10.1016/j.nicl.2015.04.017. eCollection 2015.
Elevated levels of amyloid deposition as well as white matter damage are thought to be risk factors for Alzheimer Disease (AD). Here we examined whether qualitative ratings of white matter damage predicted cognitive impairment beyond measures of amyloid.
The study examined 397 cognitively normal, 51 very mildly demented, and 11 mildly demented individuals aged 42-90 (mean 68.5). Participants obtained a T2-weighted scan as well as a positron emission tomography scan using (11)[C] Pittsburgh Compound B. Periventricular white matter hyperintensities (PVWMHs) and deep white matter hyperintensities (DWMHs) were measured on each T2 scan using the Fazekas rating scale. The effects of amyloid deposition and white matter damage were assessed using logistic regressions.
Levels of amyloid deposition (ps < 0.01), as well as ratings of PVWMH (p < 0.01) and DWMH (p < 0.05) discriminated between cognitively normal and demented individuals.
The amount of amyloid deposition and white matter damage independently predicts cognitive impairment. This suggests a diagnostic utility of qualitative white matter scales in addition to measuring amyloid levels.
淀粉样蛋白沉积水平升高以及白质损伤被认为是阿尔茨海默病（AD）的危险因素。在此，我们研究了白质损伤的定性评分是否能在淀粉样蛋白测量之外预测认知障碍。
该研究对397名认知正常、51名极轻度痴呆和11名轻度痴呆的42 - 90岁个体（平均68.5岁）进行了检查。参与者接受了T2加权扫描以及使用（11）[C]匹兹堡化合物B的正电子发射断层扫描。在每次T2扫描上使用 Fazekas评分量表测量脑室周围白质高信号（PVWMHs）和深部白质高信号（DWMHs）。使用逻辑回归评估淀粉样蛋白沉积和白质损伤的影响。
淀粉样蛋白沉积水平（p < 0.01）以及PVWMH评分（p < 0.01）和DWMH评分（p < 0.05）在认知正常和痴呆个体之间存在差异。
淀粉样蛋白沉积量和白质损伤独立预测认知障碍。这表明除了测量淀粉样蛋白水平外，白质定性量表具有诊断效用。
