• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

GGCX基因多态性对中国人群华法林维持剂量的影响：系统评价与Meta分析

Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis.

作者信息

Tian Lihong, Zhang Jinhua, Xiao Shiji, Huang Jinlong, Zhang Yuanyuan, Shen Jianzhen

机构信息

Fujian Insitute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, PR China.

Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou 350001, PR China.

出版信息

Meta Gene. 2015 Jun 5;5:43-54. doi: 10.1016/j.mgene.2015.05.003. eCollection 2015 Sep.

DOI:10.1016/j.mgene.2015.05.003
PMID:26106580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4473094/
Abstract

The meta-analysis was conducted to investigate the impact of gamma-glutamyl carboxylase (GGCX) on maintenance warfarin dose. 8 studies were included, focusing on the impact of GGCX single nucleotide polymorphisms (SNPs) on mean daily warfarin dose (MDWD). GGCX (rs699664; AA versus GG, GA versus GG, A versus GG) and GGCX (rs12714145; GA versus GG, AA versus GG, A versus GG) showed no significant differences on mean daily warfarin dose (MDWD). This meta-analysis was the first to report the relationship between GGCX SNPs and MDWD in Chinese populations. No evidence could be found in the relationship between SNPs of GGCX (rs699664 and rs12714145) and maintenance warfarin dose.

摘要

进行荟萃分析以研究γ-谷氨酰羧化酶（GGCX）对维持性华法林剂量的影响。纳入了8项研究，重点关注GGCX单核苷酸多态性（SNP）对平均每日华法林剂量（MDWD）的影响。GGCX（rs699664；AA与GG、GA与GG、A与GG）以及GGCX（rs12714145；GA与GG、AA与GG、A与GG）在平均每日华法林剂量（MDWD）上无显著差异。该荟萃分析首次报道了中国人群中GGCX SNP与MDWD之间的关系。未发现GGCX（rs699664和rs12714145）的SNP与维持性华法林剂量之间存在关联的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f1/4473094/593e72973373/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f1/4473094/57cbe45f8ab3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f1/4473094/a8b87d80965a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f1/4473094/593e72973373/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f1/4473094/57cbe45f8ab3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f1/4473094/a8b87d80965a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f1/4473094/593e72973373/gr3.jpg

相似文献

1
Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis.GGCX基因多态性对中国人群华法林维持剂量的影响：系统评价与Meta分析
Meta Gene. 2015 Jun 5;5:43-54. doi: 10.1016/j.mgene.2015.05.003. eCollection 2015 Sep.
2
Impact of CYP2C9, VKORC1 and CYP4F2 genetic polymorphisms on maintenance warfarin dosage in Han-Chinese patients: A systematic review and meta-analysis.CYP2C9、VKORC1和CYP4F2基因多态性对汉族患者华法林维持剂量的影响：一项系统评价和荟萃分析。
Meta Gene. 2016 Jul 5;9:197-209. doi: 10.1016/j.mgene.2016.07.002. eCollection 2016 Sep.
3
Impact of gamma-glutamyl carboxylase gene polymorphisms on warfarin dose requirement: a systematic review and meta-analysis.γ-谷氨酰羧化酶基因多态性对华法林剂量需求的影响：一项系统评价和荟萃分析。
Thromb Res. 2015 Apr;135(4):739-47. doi: 10.1016/j.thromres.2015.01.029. Epub 2015 Feb 7.
4
Genetic Factors Influencing Warfarin Dose in Han Chinese Population: A Systematic Review and Meta-Analysis of Cohort Studies.遗传因素对汉族人群华法林剂量的影响：队列研究的系统评价和荟萃分析。
Clin Pharmacokinet. 2023 Jun;62(6):819-833. doi: 10.1007/s40262-023-01258-y. Epub 2023 Jun 5.
5
Impact of VKORC1 gene polymorphism on interindividual and interethnic warfarin dosage requirement--a systematic review and meta analysis.VKORC1 基因多态性对个体间和种族间华法林剂量需求的影响——系统评价和荟萃分析。
Thromb Res. 2010 Apr;125(4):e159-66. doi: 10.1016/j.thromres.2009.10.017. Epub 2009 Nov 25.
6
Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.维生素K环氧化物还原酶、γ-谷氨酰羧化酶和细胞色素P450 2C9的基因型作为日本患者每日华法林剂量的决定因素
Thromb Res. 2007;120(2):181-6. doi: 10.1016/j.thromres.2006.09.007. Epub 2006 Oct 17.
7
Impact of GGCX polymorphisms on warfarin dose requirements in atrial fibrillation patients.GGCX基因多态性对房颤患者华法林剂量需求的影响。
Turk J Med Sci. 2017 Aug 23;47(4):1239-1246. doi: 10.3906/sag-1609-26.
8
Effect of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin maintenance dose in children aged less than 18 years: a protocol for systematic review and meta-analysis.CYP2C9、VKORC1和CYP4F2基因多态性对18岁以下儿童华法林维持剂量的影响：系统评价与Meta分析方案
Syst Rev. 2016 Jun 23;5(1):105. doi: 10.1186/s13643-016-0280-y.
9
Impact of VKORC1, CYP2C9, CYP1A2, UGT1A1, and GGCX polymorphisms on warfarin maintenance dose: Exploring a new algorithm in South Chinese patients accept mechanical heart valve replacement.VKORC1、CYP2C9、CYP1A2、UGT1A1 和 GGCX 多态性对华法林维持剂量的影响：在接受机械心脏瓣膜置换术的华南患者中探索新的算法。
Medicine (Baltimore). 2022 Jul 22;101(29):e29626. doi: 10.1097/MD.0000000000029626.
10
The influence of sequence variations in factor VII, gamma-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement.凝血因子VII、γ-谷氨酰羧化酶和维生素K环氧化物还原酶复合体基因序列变异对华法林剂量需求的影响。
Thromb Haemost. 2006 May;95(5):782-7.

引用本文的文献

1
Genetic Factors Influencing Warfarin Dose in Han Chinese Population: A Systematic Review and Meta-Analysis of Cohort Studies.遗传因素对汉族人群华法林剂量的影响：队列研究的系统评价和荟萃分析。
Clin Pharmacokinet. 2023 Jun;62(6):819-833. doi: 10.1007/s40262-023-01258-y. Epub 2023 Jun 5.
2
Influence of Polymorphisms on Warfarin Maintenance Dose: A Systematic Review and Meta-Analysis (rs1800566 and rs10517).基因多态性对华法林维持剂量的影响：系统评价和荟萃分析(rs1800566 和 rs10517)。
Cardiovasc Ther. 2021 Aug 12;2021:5534946. doi: 10.1155/2021/5534946. eCollection 2021.
3
Effect of Vitamin K Epoxide Reductase Complex 1 Polymorphism on Warfarin Dose Requirement among Patients in Tertiary Care Hospital.

本文引用的文献

1
Impact of gamma-glutamyl carboxylase gene polymorphisms on warfarin dose requirement: a systematic review and meta-analysis.γ-谷氨酰羧化酶基因多态性对华法林剂量需求的影响：一项系统评价和荟萃分析。
Thromb Res. 2015 Apr;135(4):739-47. doi: 10.1016/j.thromres.2015.01.029. Epub 2015 Feb 7.
2
Warfarin dosage response related pharmacogenetics in Chinese population.中国人群中与华法林剂量反应相关的药物遗传学
PLoS One. 2015 Jan 16;10(1):e0116463. doi: 10.1371/journal.pone.0116463. eCollection 2015.
3
Effect of CYP2C9, VKORC1, CYP4F2 and GGCX genetic variants on warfarin maintenance dose and explicating a new pharmacogenetic algorithm in South Indian population.
三级医院患者中维生素K环氧化物还原酶复合体1基因多态性对华法林剂量需求的影响
Int J Appl Basic Med Res. 2020 Apr-Jun;10(2):97-101. doi: 10.4103/ijabmr.IJABMR_341_18. Epub 2020 Apr 2.
4
Interpretation of the effect of CYP2C9, VKORC1 and CYP4F2 variants on warfarin dosing adjustment in Turkey.CYP2C9、VKORC1和CYP4F2基因变异对土耳其华法林剂量调整影响的解读
Mol Biol Rep. 2019 Apr;46(2):1825-1833. doi: 10.1007/s11033-019-04634-9. Epub 2019 Feb 2.
5
GGCX-Associated Phenotypes: An Overview in Search of Genotype-Phenotype Correlations.GGCX相关表型：寻找基因型-表型相关性的综述
Int J Mol Sci. 2017 Jan 25;18(2):240. doi: 10.3390/ijms18020240.
6
Association between glutathione S-transferase P1 Ile (105) Val gene polymorphism and chronic obstructive pulmonary disease: A meta-analysis based on seventeen case-control studies.谷胱甘肽S-转移酶P1 Ile（105）Val基因多态性与慢性阻塞性肺疾病的关联：基于17项病例对照研究的荟萃分析
Meta Gene. 2015 Sep 15;6:59-64. doi: 10.1016/j.mgene.2015.08.007. eCollection 2015 Dec.
CYP2C9、VKORC1、CYP4F2和GGCX基因变异对印度南部人群华法林维持剂量的影响及一种新的药物遗传学算法解析
Eur J Clin Pharmacol. 2014 Jan;70(1):47-56. doi: 10.1007/s00228-013-1581-x. Epub 2013 Sep 10.
4
Association of genetic polymorphisms with warfarin dose requirements in Chinese patients.中国患者基因多态性与华法林剂量需求的关联
Genet Test Mol Biomarkers. 2013 Dec;17(12):932-6. doi: 10.1089/gtmb.2013.0303. Epub 2013 Aug 13.
5
Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis.CYP2C9 和 VKORC1 对患者华法林反应的影响：系统评价和荟萃分析。
PLoS One. 2012;7(8):e44064. doi: 10.1371/journal.pone.0044064. Epub 2012 Aug 29.
6
Pharmacogenetic aspects of coumarinic oral anticoagulant therapies.香豆素类口服抗凝治疗的药物遗传学方面
Indian J Clin Biochem. 2011 Jul;26(3):222-9. doi: 10.1007/s12291-011-0133-3. Epub 2011 May 1.
7
Retrospective evidence for clinical validity of expanded genetic model in warfarin dose optimization in a South Indian population.印度南部人群中，华法林剂量优化扩展遗传模型的临床有效性的回顾性证据。
Pharmacogenomics. 2012 Jun;13(8):869-78. doi: 10.2217/pgs.12.62.
8
Integrating interacting drugs and genetic variations to improve the predictability of warfarin maintenance dose in Chinese patients.整合相互作用的药物和遗传变异，以提高中国患者华法林维持剂量的可预测性。
Pharmacogenet Genomics. 2012 Mar;22(3):176-82. doi: 10.1097/FPC.0b013e32834f45f9.
9
Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis.CYP4F2 基因型对华法林剂量需求的影响：系统评价和荟萃分析。
Thromb Res. 2012 Jul;130(1):38-44. doi: 10.1016/j.thromres.2011.11.043. Epub 2011 Dec 20.
10
Proposal of pharmacogenetics-based warfarin dosing algorithm in Korean patients.基于药物遗传学的华法林剂量算法在韩国患者中的应用建议。
J Hum Genet. 2011 Apr;56(4):290-5. doi: 10.1038/jhg.2011.4. Epub 2011 Feb 17.