GGCX基因多态性对中国人群华法林维持剂量的影响：系统评价与Meta分析
Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis.
作者信息
Tian Lihong, Zhang Jinhua, Xiao Shiji, Huang Jinlong, Zhang Yuanyuan, Shen Jianzhen
机构信息
Fujian Insitute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, PR China.
Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou 350001, PR China.
出版信息
Meta Gene. 2015 Jun 5;5:43-54. doi: 10.1016/j.mgene.2015.05.003. eCollection 2015 Sep.
The meta-analysis was conducted to investigate the impact of gamma-glutamyl carboxylase (GGCX) on maintenance warfarin dose. 8 studies were included, focusing on the impact of GGCX single nucleotide polymorphisms (SNPs) on mean daily warfarin dose (MDWD). GGCX (rs699664; AA versus GG, GA versus GG, A versus GG) and GGCX (rs12714145; GA versus GG, AA versus GG, A versus GG) showed no significant differences on mean daily warfarin dose (MDWD). This meta-analysis was the first to report the relationship between GGCX SNPs and MDWD in Chinese populations. No evidence could be found in the relationship between SNPs of GGCX (rs699664 and rs12714145) and maintenance warfarin dose.
进行荟萃分析以研究γ-谷氨酰羧化酶（GGCX）对维持性华法林剂量的影响。纳入了8项研究，重点关注GGCX单核苷酸多态性（SNP）对平均每日华法林剂量（MDWD）的影响。GGCX（rs699664；AA与GG、GA与GG、A与GG）以及GGCX（rs12714145；GA与GG、AA与GG、A与GG）在平均每日华法林剂量（MDWD）上无显著差异。该荟萃分析首次报道了中国人群中GGCX SNP与MDWD之间的关系。未发现GGCX（rs699664和rs12714145）的SNP与维持性华法林剂量之间存在关联的证据。
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