铜（II）：硫醇体系对线性B-DNA切割时的明显序列偏好性。
Apparent sequence preference in cleavage of linear B-DNA by the Cu(II):thiol system.
作者信息
John D C, Douglas K T
机构信息
Department of Pharmacy, University of Manchester, UK.
出版信息
Biochem Biophys Res Commun. 1989 Dec 29;165(3):1235-42. doi: 10.1016/0006-291x(89)92734-4.
PMID:2610689
Abstract
Cleavage of a linear tyr T fragment of duplex DNA by Cu(II):thiol combinations occurs with apparent sequence preference. The sequence selectivity was unaffected by the size, chirality or substitution pattern of the monothiol partner, presumably indicating that the Cu(II):RSH system is probing some local conformational/dynamic aspect of the DNA.
摘要
铜（II）与硫醇组合对双链DNA的线性酪氨酸T片段的切割具有明显的序列偏好。序列选择性不受单硫醇配体的大小、手性或取代模式的影响，这大概表明铜（II）：RSH系统正在探测DNA的某些局部构象/动力学方面。
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