铑催化氧化导向的芳基邻位 C-H 乙烯基化反应。
Rh-catalyzed oxidizing group-directed ortho C-H vinylation of arenes by vinylstannanes.
机构信息
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
出版信息
Chem Commun (Camb). 2015 Sep 7;51(69):13362-4. doi: 10.1039/c5cc04211a.
PMID:26106954
Abstract
An efficient method for the synthesis of functionalized vinyl arenes from the reaction of N-methoxybenzamides or N-phenoxyacetamides with vinylstannanes via rhodium(iii)-catalyzed C-H activation is described. The application of the methodology for the synthesis of a natural product thalactamine and a 7-membered ring oxepine are also demonstrated.
摘要
描述了一种通过铑（III）催化的 C-H 活化，由 N-甲氧基苯甲酰胺或 N-苯氧乙酰胺与乙烯基锡烷反应合成功能化的乙烯基芳烃的有效方法。该方法学还用于合成天然产物噻拉嗪和 7 元环氧杂环庚烷的应用也得到了展示。
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