米纳斯吉拉斯联邦大学大学医院收治的重症肌无力患者的临床概况
Clinical profile of patients with myasthenia gravis followed at the University Hospital, Federal University of Minas Gerais.
作者信息
Mourão Aline Mansueto, Barbosa Luiz Sérgio Mageste, Comini-Frota Elizabeth Regina, Freitas Denise da Silva, Gomez Rodrigo Santiago, Burns Ted M, Lemos Stela Maris Aguiar, Teixeira Antonio Lúcio
机构信息
Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Neurology Service, Clinics Hospital, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
出版信息
Rev Assoc Med Bras (1992). 2015 Mar-Apr;61(2):156-60. doi: 10.1590/1806-9282.61.02.156.
OBJECTIVE
to determine the clinical profile of patients with myasthenia gravis (MG); followed at the Neuromuscular Diseases Clinic of the University Hospital, Federal University of Minas Gerais, Brazil, and to compare it with other Brazilian case series.
METHODS
sociodemographic and clinical data were collected from patients, and a systematic literature review performed, focusing on national studies on the clinical profile of MG patients.
RESULTS
sixty nine patients were enrolled in the study. Fifty five (91%) subjects were female and the mean age (SD) was 37.6 (± 11.4) years. The mean disease duration was 14.1 years. Regarding treatment, prednisone was the most used strategy (64%), followed by the use of azathioprine (43%). There was no difference between thymectomized (42) and non-thymectomized (27) patients regarding disease severity and medication use.
CONCLUSION
clinical and socio-demographic features of this MG sample from a University-based clinic resemble those reported in other Brazilian series and in the international literature.
目的
确定在巴西米纳斯吉拉斯联邦大学大学医院神经肌肉疾病诊所接受随访的重症肌无力（MG）患者的临床特征，并将其与巴西其他病例系列进行比较。
方法
收集患者的社会人口统计学和临床数据，并进行系统的文献综述，重点关注巴西关于MG患者临床特征的研究。
结果
69例患者纳入本研究。55例（91%）为女性，平均年龄（标准差）为37.6（±11.4）岁。平均病程为14.1年。在治疗方面，泼尼松是最常用的策略（64%），其次是使用硫唑嘌呤（43%）。胸腺切除患者（42例）和未行胸腺切除患者（27例）在疾病严重程度和药物使用方面无差异。
结论
该来自大学诊所的MG样本的临床和社会人口统计学特征与巴西其他系列报道以及国际文献中的特征相似。
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