Gao Li, Li Cuidi, Chen Fangping, Liu Changsheng
The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, People's Republic of China. Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, People's Republic of China. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
Biomed Mater. 2015 Jun 24;10(3):035009. doi: 10.1088/1748-6041/10/3/035009.
A novel elastomeric material, poly(1,8-octanediol-co-citrate) (POC), has demonstrated tremendous versatility because of its advantageous toughness, tunable degradation properties, and efficient drug release capability. In this study, POC was used to improve the mechanical performance of β-tricalcium phosphate (β-Ca3(PO4)2, β-TCP). (3D) β-TCP/POC composite scaffolds were fabricated by a 3D printing technique based on the freeform fabrication system with micro-droplet jetting (FFS-MDJ). The physiochemical properties, compressive modulus, drug release behavior, and cell response of β-TCP/POC composite scaffolds were systematically investigated. The results showed that β-TCP/POC scaffolds had uniform macropores of 300-400 μm, porosity of approximately 45%, biodegradability in phosphate-buffered saline, and high compressive modulus of 50-75 MPa. With the incorporation of POC into β-TCP, the toughness of the composite scaffolds was improved significantly. Moreover, β-TCP/POC scaffolds exhibited sustained drug (ibuprofen (IBU)) release capability. Additionally, β-TCP/POC scaffolds facilitated C2C12 cell attachment and proliferation. It was indicated that the 3D-printed porous β-TCP/POC scaffolds with high compressive modulus and good drug delivery performance might be a promising candidate for bone defect repair.
一种新型弹性体材料聚（1,8 - 辛二醇 - 共 - 柠檬酸酯）（POC），因其具有优异的韧性、可调节的降解性能和高效的药物释放能力而展现出巨大的通用性。在本研究中，POC被用于改善β - 磷酸三钙（β - Ca3(PO4)2，β - TCP）的力学性能。基于微滴喷射自由成型制造系统（FFS - MDJ）的3D打印技术制备了（3D）β - TCP/POC复合支架。系统研究了β - TCP/POC复合支架的物理化学性质、压缩模量、药物释放行为和细胞反应。结果表明，β - TCP/POC支架具有300 - 400μm的均匀大孔、约45%的孔隙率、在磷酸盐缓冲盐水中的生物降解性以及50 - 75MPa的高压缩模量。通过将POC掺入β - TCP中，复合支架的韧性得到显著提高。此外，β - TCP/POC支架表现出持续的药物（布洛芬（IBU））释放能力。另外，β - TCP/POC支架促进了C2C12细胞的附着和增殖。结果表明，具有高压缩模量和良好药物递送性能的3D打印多孔β - TCP/POC支架可能是骨缺损修复的一个有前途的候选材料。
