Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.
Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, 2215B Garland Ave, 1235 MRBIV, Nashville, TN, 37232, USA.
Curr Osteoporos Rep. 2017 Aug;15(4):247-254. doi: 10.1007/s11914-017-0385-9.
Bone is a structurally unique microenvironment that presents many challenges for the development of 3D models for studying bone physiology and diseases, including cancer. As researchers continue to investigate the interactions within the bone microenvironment, the development of 3D models of bone has become critical.
3D models have been developed that replicate some properties of bone, but have not fully reproduced the complex structural and cellular composition of the bone microenvironment. This review will discuss 3D models including polyurethane, silk, and collagen scaffolds that have been developed to study tumor-induced bone disease. In addition, we discuss 3D printing techniques used to better replicate the structure of bone. 3D models that better replicate the bone microenvironment will help researchers better understand the dynamic interactions between tumors and the bone microenvironment, ultimately leading to better models for testing therapeutics and predicting patient outcomes.
骨骼是一种结构独特的微环境，给研究骨骼生理学和疾病（包括癌症）的 3D 模型的发展带来了诸多挑战。随着研究人员不断探索骨骼微环境中的相互作用，骨骼 3D 模型的发展变得至关重要。
已经开发出了一些能够复制骨骼某些特性的 3D 模型，但尚未完全复制骨骼微环境的复杂结构和细胞组成。本综述将讨论为研究肿瘤诱导性骨病而开发的包括聚氨酯、丝和胶原支架在内的 3D 模型。此外，我们还讨论了用于更好地复制骨骼结构的 3D 打印技术。更好地复制骨骼微环境的 3D 模型将帮助研究人员更好地理解肿瘤与骨骼微环境之间的动态相互作用，最终为测试治疗方法和预测患者预后提供更好的模型。
