工程化肿瘤和骨 3D 模型，以了解肿瘤诱导性骨疾病并改善治疗方法。
Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments.
机构信息
Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.
Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, 2215B Garland Ave, 1235 MRBIV, Nashville, TN, 37232, USA.
出版信息
Curr Osteoporos Rep. 2017 Aug;15(4):247-254. doi: 10.1007/s11914-017-0385-9.
Abstract
PURPOSE OF REVIEW
Bone is a structurally unique microenvironment that presents many challenges for the development of 3D models for studying bone physiology and diseases, including cancer. As researchers continue to investigate the interactions within the bone microenvironment, the development of 3D models of bone has become critical.
RECENT FINDINGS
3D models have been developed that replicate some properties of bone, but have not fully reproduced the complex structural and cellular composition of the bone microenvironment. This review will discuss 3D models including polyurethane, silk, and collagen scaffolds that have been developed to study tumor-induced bone disease. In addition, we discuss 3D printing techniques used to better replicate the structure of bone. 3D models that better replicate the bone microenvironment will help researchers better understand the dynamic interactions between tumors and the bone microenvironment, ultimately leading to better models for testing therapeutics and predicting patient outcomes.
摘要
目的综述
骨骼是一种结构独特的微环境，给研究骨骼生理学和疾病（包括癌症）的 3D 模型的发展带来了诸多挑战。随着研究人员不断探索骨骼微环境中的相互作用，骨骼 3D 模型的发展变得至关重要。
最近的发现
已经开发出了一些能够复制骨骼某些特性的 3D 模型，但尚未完全复制骨骼微环境的复杂结构和细胞组成。本综述将讨论为研究肿瘤诱导性骨病而开发的包括聚氨酯、丝和胶原支架在内的 3D 模型。此外，我们还讨论了用于更好地复制骨骼结构的 3D 打印技术。更好地复制骨骼微环境的 3D 模型将帮助研究人员更好地理解肿瘤与骨骼微环境之间的动态相互作用，最终为测试治疗方法和预测患者预后提供更好的模型。
相似文献
1
Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments.工程化肿瘤和骨 3D 模型，以了解肿瘤诱导性骨疾病并改善治疗方法。
Curr Osteoporos Rep. 2017 Aug;15(4):247-254. doi: 10.1007/s11914-017-0385-9.
2
3D bone models to study the complex physical and cellular interactions between tumor and the bone microenvironment.三维骨模型用于研究肿瘤与骨微环境之间复杂的物理和细胞相互作用。
J Cell Biochem. 2018 Jul;119(7):5053-5059. doi: 10.1002/jcb.26774. Epub 2018 Mar 30.
3
[CYTOCOMPATIBILITY AND PREPARATION OF BONE TISSUE ENGINEERING SCAFFOLD BY COMBINING LOW TEMPERATURE THREE DIMENSIONAL PRINTING AND VACUUM FREEZE-DRYING TECHNIQUES].[低温三维打印与真空冷冻干燥技术相结合制备骨组织工程支架及其细胞相容性]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2016 Mar;30(3):292-7.
4
The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics.使用基于胶原蛋白的支架来模拟前列腺癌骨转移，具有评估纳米颗粒基因治疗药物递送的潜力。
Biomaterials. 2015 Oct;66:53-66. doi: 10.1016/j.biomaterials.2015.07.019. Epub 2015 Jul 14.
5
Breast cancer models: Engineering the tumor microenvironment.乳腺癌模型：工程化肿瘤微环境。
Acta Biomater. 2020 Apr 1;106:1-21. doi: 10.1016/j.actbio.2020.02.006. Epub 2020 Feb 9.
6
Engineering a Novel 3D Printed Vascularized Tissue Model for Investigating Breast Cancer Metastasis to Bone.构建一种新型3D打印血管化组织模型用于研究乳腺癌向骨转移
Adv Healthc Mater. 2020 Aug;9(15):e1900924. doi: 10.1002/adhm.201900924. Epub 2019 Dec 17.
7
3D-printed bioceramic scaffolds: From bone tissue engineering to tumor therapy.3D 打印生物陶瓷支架：从骨组织工程到肿瘤治疗。
Acta Biomater. 2018 Oct 1;79:37-59. doi: 10.1016/j.actbio.2018.08.026. Epub 2018 Aug 28.
8
3D Scaffolds with Different Stiffness but the Same Microstructure for Bone Tissue Engineering.用于骨组织工程的具有不同刚度但相同微观结构的 3D 支架。
ACS Appl Mater Interfaces. 2015 Jul 29;7(29):15790-802. doi: 10.1021/acsami.5b02662. Epub 2015 Jul 17.
9
Polyurethane foam scaffold as in vitro model for breast cancer bone metastasis.聚氨酯泡沫支架作为乳腺癌骨转移的体外模型。
Acta Biomater. 2017 Nov;63:306-316. doi: 10.1016/j.actbio.2017.09.017. Epub 2017 Sep 18.
10
3D printing of mesoporous bioactive glass/silk fibroin composite scaffolds for bone tissue engineering.介孔生物活性玻璃/丝素蛋白复合支架的 3D 打印用于骨组织工程。
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109731. doi: 10.1016/j.msec.2019.05.016. Epub 2019 May 10.
引用本文的文献
1
Exploring bone-tumor interactions through 3D models: Implications for primary and metastatic cancers.通过三维模型探索骨肿瘤相互作用：对原发性和转移性癌症的启示
J Bone Oncol. 2025 Jun 17;53:100698. doi: 10.1016/j.jbo.2025.100698. eCollection 2025 Aug.
2
Innovative Ink-Based 3D Hydrogel Bioprinted Formulations for Tissue Engineering Applications.用于组织工程应用的基于墨水的创新型3D水凝胶生物打印配方
Gels. 2024 Dec 17;10(12):831. doi: 10.3390/gels10120831.
3
Feasibility and barriers to rapid establishment of patient-derived primary osteosarcoma cell lines in clinical management.在临床管理中快速建立患者来源的原发性骨肉瘤细胞系的可行性及障碍
iScience. 2024 Jun 19;27(9):110251. doi: 10.1016/j.isci.2024.110251. eCollection 2024 Sep 20.
4
Advantages of Using 3D Spheroid Culture Systems in Toxicological and Pharmacological Assessment for Osteogenesis Research.在成骨研究的毒理学和药理学评估中使用3D球体培养系统的优势
Int J Mol Sci. 2024 Feb 21;25(5):2512. doi: 10.3390/ijms25052512.
5
The application of custom 3D-printed prostheses with ultra-short stems in the reconstruction of bone defects: a single center analysis.定制超短柄3D打印假体在骨缺损重建中的应用：单中心分析
Front Bioeng Biotechnol. 2024 Jan 25;12:1349819. doi: 10.3389/fbioe.2024.1349819. eCollection 2024.
6
The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors.3D 打印的由多种生物材料组成的生物支架在治疗骨肿瘤中的双重作用。
Int J Nanomedicine. 2023 Jan 15;18:293-305. doi: 10.2147/IJN.S390500. eCollection 2023.
7
3D Printing and Bioprinting to Model Bone Cancer: The Role of Materials and Nanoscale Cues in Directing Cell Behavior.用于模拟骨癌的3D打印和生物打印：材料和纳米级信号在引导细胞行为中的作用
Cancers (Basel). 2021 Aug 12;13(16):4065. doi: 10.3390/cancers13164065.
8
Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications.用于组织工程和再生医学应用的支架策略
Materials (Basel). 2019 Jun 5;12(11):1824. doi: 10.3390/ma12111824.
9
Bone metastasis treatment modeling via optimal control.通过最优控制进行骨转移治疗建模
J Math Biol. 2019 Jan;78(1-2):497-526. doi: 10.1007/s00285-018-1281-3. Epub 2018 Aug 21.
10
Hallmarks of Bone Metastasis.骨转移的特征。
Calcif Tissue Int. 2018 Feb;102(2):141-151. doi: 10.1007/s00223-017-0362-4. Epub 2017 Nov 14.
本文引用的文献
1
Surface-enrichment with hydroxyapatite nanoparticles in stereolithography-fabricated composite polymer scaffolds promotes bone repair.立体光刻制造的复合聚合物支架表面富含纳米羟基磷灰石可促进骨修复。
Acta Biomater. 2017 May;54:386-398. doi: 10.1016/j.actbio.2017.03.006. Epub 2017 Mar 7.
2
Fabrication of a Highly Aligned Neural Scaffold via a Table Top Stereolithography 3D Printing and Electrospinning<sup/>.通过桌面立体光刻3D打印和静电纺丝制造高度对齐的神经支架
Tissue Eng Part A. 2017 Jun;23(11-12):491-502. doi: 10.1089/ten.TEA.2016.0353. Epub 2017 Jan 11.
3
3D scaffold with effective multidrug sequential release against bacteria biofilm.具有有效多药序贯释放功能以对抗细菌生物膜的3D支架。
Acta Biomater. 2017 Feb;49:113-126. doi: 10.1016/j.actbio.2016.11.028. Epub 2016 Nov 11.
4
PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture.用于三维乳腺癌细胞培养的聚乙二醇-纤维蛋白原水凝胶
J Biomed Mater Res A. 2017 Jan;105(1):236-252. doi: 10.1002/jbm.a.35899. Epub 2016 Oct 14.
5
Preparation and characterization of aligned porous PCL/zein scaffolds as drug delivery systems via improved unidirectional freeze-drying method.通过改进的单向冷冻干燥法制备用于药物递送系统的取向多孔聚己内酯/玉米醇溶蛋白支架及其表征
Mater Sci Eng C Mater Biol Appl. 2016 Nov 1;68:613-622. doi: 10.1016/j.msec.2016.06.009. Epub 2016 Jun 8.
6
Three-Dimensional Mechanical Loading Modulates the Osteogenic Response of Mesenchymal Stem Cells to Tumor-Derived Soluble Signals.三维机械负荷调节间充质干细胞对肿瘤衍生可溶性信号的成骨反应。
Tissue Eng Part A. 2016 Aug;22(15-16):1006-15. doi: 10.1089/ten.TEA.2016.0153. Epub 2016 Aug 1.
7
3D Printing of Tissue Engineered Constructs for In Vitro Modeling of Disease Progression and Drug Screening.用于疾病进展体外建模和药物筛选的组织工程构建体的3D打印
Ann Biomed Eng. 2017 Jan;45(1):164-179. doi: 10.1007/s10439-016-1640-4. Epub 2016 May 11.
8
Growth of human breast tissues from patient cells in 3D hydrogel scaffolds.利用患者细胞在三维水凝胶支架中培养人乳腺组织。
Breast Cancer Res. 2016 Mar 1;18(1):19. doi: 10.1186/s13058-016-0677-5.
9
Comparative analysis of tumor spheroid generation techniques for differential in vitro drug toxicity.用于差异体外药物毒性的肿瘤球体生成技术的比较分析
Oncotarget. 2016 Mar 29;7(13):16948-61. doi: 10.18632/oncotarget.7659.
10
A 3D bioprinting system to produce human-scale tissue constructs with structural integrity.一种 3D 生物打印系统，可用于生成具有结构完整性的人体尺度组织构建体。
Nat Biotechnol. 2016 Mar;34(3):312-9. doi: 10.1038/nbt.3413. Epub 2016 Feb 15.
Zotero 插件