Nissen-Meyer R, Høst H, Kjellgren K
Acta Oncol. 1989;28(6):903-6. doi: 10.3109/02841868909092329.
Eleven hundred and sixteen primary female breast cancer patients received one short perioperative chemotherapy course. The node negative patients were randomised between immunotherapy (corynebacterium parvum s.c. around the scar 2 weeks after mastectomy), or no further adjuvant therapy. A moderate, but significant delaying effect was observed, without side effects. The node positive patients were randomised to four groups: 1) the same immunotherapy as in the node negative patients, 2) CMF for 1 year, 3) combination of these two treatments, or 4) no further adjuvant therapy. The prolonged chemotherapy had a significant positive effect, but also considerable and distressing side effects. The immunotherapy had a non-significant negative effect in the node positive patients, but without side effects.
1116名原发性女性乳腺癌患者接受了一个短疗程的围手术期化疗。淋巴结阴性患者被随机分为免疫治疗组（乳房切除术后2周在瘢痕周围皮下注射短小棒状杆菌）或不进行进一步辅助治疗组。观察到有中度但显著的延迟效应，且无副作用。淋巴结阳性患者被随机分为四组：1）与淋巴结阴性患者相同的免疫治疗组；2）CMF方案治疗1年组；3）这两种治疗方法联合组；4）不进行进一步辅助治疗组。延长化疗有显著的积极效果，但也有相当多令人痛苦的副作用。免疫治疗在淋巴结阳性患者中有不显著的负面效果，但无副作用。
