Brun Elodie, Safer Abdelmounaim, Carreaux François, Bourahla Khadidja, L'helgoua'ch Jean-Martial, Bazureau Jean-Pierre, Villalgordo Jose Manuel
Institut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, France.
LSOA-Laboratoire de Synthèse Organique Appliquée, Department of chemistry, Oran 1 University, 1524 Oran, Algeria.
Molecules. 2015 Jun 23;20(6):11617-31. doi: 10.3390/molecules200611617.
We here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in the presence of boric acid under microwave conditions. Implementation of the reaction is simple, healthy and environmentally friendly owing to the use of a non-toxic catalyst coupled to a solvent-free procedure. A large variety of known or novel compounds have thus been prepared, including with substrates bearing acid or base-sensitive functional groups.
我们在此公开了一种新的方法，即在微波条件下，在硼酸存在下，使苯乙酮衍生物和活性亚甲基化合物与醛进行缩合反应。由于使用了无毒催化剂并采用无溶剂程序，该反应的实施简单、健康且环保。由此制备了多种已知或新型化合物，包括带有酸或碱敏感官能团的底物。
