微波辅助的高效无溶剂 Knoevenagel 缩合反应。一种使用多孔羟磷灰石作为催化剂的可持续方法。
Microwave-assisted and efficient solvent-free knoevenagel condensation. A sustainable protocol using porous calcium hydroxyapatite as catalyst.
机构信息
Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Université Mohammed V-Agdal, Faculté des Sciences, B.P. 1014 R.P, Rabat, Maroc.
出版信息
Molecules. 2010 Feb 4;15(2):813-23. doi: 10.3390/molecules15020813.
A sustainable Knoevenagel condensation of a series of aldehydes with malononitrile and ethyl cyanoacetate is described. The process is based on the combination of microwave activation and hydroxyapatite catalysis under solvent-free conditions. Products are obtained in and high yields after short reaction times. The effects of the specific surface of porous calcium hydroxyapatite and microwave activation are discussed.
描述了一系列醛与丙二腈和氰基乙酸乙酯的可持续 Knoevenagel 缩合反应。该过程基于微波激活和无溶剂条件下羟基磷灰石催化的结合。在短反应时间后，以高收率获得产物。讨论了多孔羟基磷灰石的比表面积和微波激活的影响。
Zotero 插件