小窝相关蛋白在健康与疾病中的表观遗传修饰

Low Jin-Yih, Nicholson Helen D

Department of Anatomy, Otago School of Medical Sciences, University of Otago, P.O. Box 913, Dunedin, 9054, New Zealand.

BMC Genet. 2015 Jun 26;16:71. doi: 10.1186/s12863-015-0231-y.

Caveolae are small, "omega-shaped" invaginations at the plasma membrane of the cell which are involved in a variety of processes including cholesterol transport, potocytosis and cell signalling. Within caveolae there are caveolae-associated proteins, and changes in expression of these molecules have been described to play a role in the pathophysiology of various diseases including cancer and cardiovascular disease. Evidence is beginning to accumulate that epigenetic processes may regulate the expression of these caveolae related genes, and hence contribute to disease progression. Here, we summarize the current knowledge of the role of epigenetic modification in regulating the expression of these caveolae related genes and how this relates to changes in cellular physiology and in health and disease.

小窝是细胞质膜上微小的“Ω形”内陷结构，参与多种过程，包括胆固醇转运、胞饮作用和细胞信号传导。小窝内存在与小窝相关的蛋白质，这些分子表达的变化已被描述在包括癌症和心血管疾病在内的各种疾病的病理生理学中发挥作用。越来越多的证据表明，表观遗传过程可能调节这些与小窝相关基因的表达，从而促进疾病进展。在此，我们总结了目前关于表观遗传修饰在调节这些与小窝相关基因表达中的作用的知识，以及这与细胞生理学变化以及健康和疾病的关系。