印度北部勒克瑙儿童病毒性肠胃炎的病因
Aetiology of childhood viral gastroenteritis in Lucknow, north India.
作者信息
Gupta Shilpi, Singh K P, Jain Amita, Srivastava Shilpi, Kumar Vishwajeet, Singh Mastan
机构信息
Department of Microbiology, King George's Medical University, Lucknow, India.
出版信息
Indian J Med Res. 2015 Apr;141(4):469-72. doi: 10.4103/0971-5916.159298.
BACKGROUND & OBJECTIVES: Due to limited availability of data on viral aetiology of acute gastroenteritis in north India, the present study was planned to detect rotavirus, norovirus, sapovirus and astrovirus in stool samples of both in hospitalized and non-hospitalized children less than five years of age presenting with acute gastroenteritis.
METHODS
A total of 278 stool samples from equal number of children were tested for rotavirus antigen using ELISA and for norovirus, sapovirus and astroviruses by reverse transcription (RT)-PCR.
RESULTS
Of the 169 samples from hospitalized patients, rotavirus, norovirus, sapovirus and astrovirus were detected in 19.5, 2.3, 3.5 and 2.9 per cent samples, respectively. Of the 109 samples collected from the non-hospitalized patients, frequency of rotavirus and sapovirus detection was 9.1 and 1.8 per cent, respectively while norovirus and astrovirus were not detected.
INTERPRETATION & CONCLUSIONS: Rotavirus was the most frequent cause of viral gastroenteritis in both hospitalized and non-hospitalized children. Maximum positivity of the viruses was seen in children less than two years of age.
背景与目的
由于印度北部急性胃肠炎病毒病因的数据有限，本研究旨在检测5岁以下患急性胃肠炎的住院和非住院儿童粪便样本中的轮状病毒、诺如病毒、札如病毒和星状病毒。
方法
对278名儿童数量相等的粪便样本进行检测，采用ELISA法检测轮状病毒抗原，采用逆转录（RT）-PCR法检测诺如病毒、札如病毒和星状病毒。
结果
在169份住院患者样本中，轮状病毒、诺如病毒、札如病毒和星状病毒的检出率分别为19.5%、2.3%、3.5%和2.9%。在109份非住院患者样本中，轮状病毒和札如病毒的检出率分别为9.1%和1.8%，未检测到诺如病毒和星状病毒。
解读与结论
轮状病毒是住院和非住院儿童病毒性胃肠炎最常见的病因。病毒阳性率最高的是2岁以下儿童。
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