Bearn J, Franey C, Arendt J, Checkley S A
Institute of Psychiatry, University of Surrey.
Br J Psychiatry. 1989 Sep;155:341-7. doi: 10.1192/bjp.155.3.341.
Urinary 6-sulphatoxymelatonin (alpha MT6s) excretion was measured after one day and one, two and three weeks of desipramine treatment in eight depressed patients. There was significant increase in the urinary excretion of alpha MT6s after one week of treatment, and at no time was there any decrease in alpha MT6s excretion. These findings are opposed to the hypothesis that desipramine reduces noradrenergic neurotransmission in the human pineal. In a further five patients whose depression was resistant to desipramine alone, urinary alpha MT6s excretion was measured during treatment with adjunctive L-triiodothyronine (T3). There was no change in alpha MT6s excretion, and thus the previously reported potentiation of the efficacy of tricyclic antidepressants in combination with T3 does not appear to be mediated through an alteration in noradrenergic neurotransmission.
在8名抑郁症患者中，测定了地昔帕明治疗1天、1周、2周和3周后的尿6-硫酸氧褪黑素（αMT6s）排泄量。治疗1周后，αMT6s的尿排泄量显著增加，且在任何时候αMT6s排泄量均未减少。这些发现与地昔帕明降低人松果体中去甲肾上腺素能神经传递的假说相反。在另外5名仅对地昔帕明耐药的抑郁症患者中，在联合使用L-三碘甲状腺原氨酸（T3）治疗期间测定了尿αMT6s排泄量。αMT6s排泄量没有变化，因此，先前报道的三环类抗抑郁药与T3联合使用时疗效增强的现象似乎不是通过去甲肾上腺素能神经传递的改变介导的。
