鲁比孔河将自噬切换为 LAP。
Rubicon swaps autophagy for LAP.
机构信息
MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
1] MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge, CB2 0QH, UK [2] Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
出版信息
Nat Cell Biol. 2015 Jul;17(7):843-5. doi: 10.1038/ncb3197.
Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubicon in the immune response to Aspergillus fumigatus.
吞噬细胞将它们的猎物吞噬到称为吞噬体的囊泡结构中，其中一定比例的吞噬体通过一种称为 LC3 相关的吞噬作用（LAP）的过程被划定为增强成熟。现在已经揭示了 LAP 的分子要求，确立了蛋白质 Rubicon 在曲霉免疫反应中的核心作用。
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