功能性MICA-129多态性与慢性恰加斯心脏病严重程度的关联。
Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.
作者信息
Ayo Christiane Maria, Oliveira Amanda Priscila de, Camargo Ana Vitória da Silveira, Mattos Cinara Cássia Brandão de, Bestetti Reinaldo Bulgarelli, Mattos Luiz Carlos de
机构信息
Laboratório de Imunogenética, Departamento de Biologia Molecular.
Departamento de Cardiologia e Cirurgia Cardiovascular, Faculdade de Medicina de São José do Rio Preto, São Paulo, Brazil.
出版信息
Clin Infect Dis. 2015 Oct 15;61(8):1310-3. doi: 10.1093/cid/civ540. Epub 2015 Jun 30.
Abstract
MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD.
摘要
MICA-129多态性影响MICA分子与NKG2D受体的结合亲和力，并影响效应细胞功能。基因型met/met与慢性恰加斯心脏病患者左心室收缩功能障碍（LVSD）的严重程度相关，而val/val基因型与无LVSD相关。
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