久坐时间与行动不便的老年人的代谢综合征有关——LIFE研究。
Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations--The LIFE Study.
作者信息
Mankowski Robert T, Aubertin-Leheudre Mylene, Beavers Daniel P, Botoseneanu Anda, Buford Thomas W, Church Timothy, Glynn Nancy W, King Abby C, Liu Christine, Manini Todd M, Marsh Anthony P, McDermott Mary, Nocera Joe R, Pahor Marco, Strotmeyer Elsa S, Anton Stephen D
机构信息
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA; Department of Rehabilitation Medicine, Erasmus University Medical Centre, Rotterdam 3000CA, The Netherlands.
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA; Department of Kinanthropology, University of Quebec, Montreal, Quebec H2X1Y4, Canada.
出版信息
Exp Gerontol. 2015 Oct;70:32-6. doi: 10.1016/j.exger.2015.06.018. Epub 2015 Jun 28.
BACKGROUND
Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults.
METHODS
The association between objectively measured sedentary time (accelerometry) with MetS and MetS components was examined in a large sample of older adults with mobility limitations (N=1198; mean age=78.7 ± 5.3 years) enrolled in the Lifestyle Interventions and Independence for Elders (LIFE) study. Participants were divided into tertiles according to percentage of daily sedentary time, and the relation between sedentary time with MetS and MetS components was examined after adjusting for age, sex, ethnicity, and BMI.
RESULTS
Participants in the highest sedentary time tertile had significantly higher odds of MetS (OR=1.54) (95% CI 1.13 to 2.11) in comparison with participants in the lowest tertile (p=0.03). Participants in the highest sedentary time tertile had larger waist circumference (p=0.0001) and lower HDL-C (p=0.0003) than participants in the lowest sedentary time tertile.
CONCLUSIONS
Sedentary time was strongly related to higher odds of MetS. These results, based on objectively measured sedentary time, suggest that sedentary time may represent an important risk factor for the development of MetS in older adults with high likelihood for disability.
背景
流行病学和客观研究报告称，在年轻及中年成年人中，久坐时间与代谢综合征（MetS）及其危险因素的较低风险之间存在关联。迄今为止，关于老年人久坐时间与MetS之间关联的客观数据尚缺。
方法
在纳入“老年人生活方式干预与独立性研究”（LIFE研究）的大量行动不便的老年人样本（N = 1198；平均年龄 = 78.7 ± 5.3岁）中检查了客观测量的久坐时间（加速度计测量）与MetS及其组成部分之间的关联。参与者根据每日久坐时间百分比分为三分位数，并在调整年龄、性别、种族和体重指数后检查久坐时间与MetS及其组成部分之间的关系。
结果
与最低三分位数的参与者相比，最高久坐时间三分位数的参与者患MetS的几率显著更高（OR = 1.54）（95% CI 1.13至2.11）（p = 0.03）。最高久坐时间三分位数的参与者比最低久坐时间三分位数的参与者腰围更大（p = 0.0001）且高密度脂蛋白胆固醇（HDL-C）更低（p = 0.0003）。
结论
久坐时间与患MetS的较高几率密切相关。这些基于客观测量的久坐时间的结果表明，久坐时间可能是残疾可能性较高的老年人发生MetS的一个重要危险因素。
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