Akuta Norio, Suzuki Fumitaka, Kobayashi Masahiro, Sezaki Hitomi, Kawamura Yusuke, Hosaka Tetsuya, Kobayashi Mariko, Saitoh Satoshi, Suzuki Yoshiyuki, Arase Yasuji, Ikeda Kenji, Kumada Hiromitsu
Department of Hepatology, Toranomon Hospital, and Okinaka Memorial Institute for Medical Research, Tokyo, Japan
Department of Hepatology, Toranomon Hospital, and Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
J Clin Microbiol. 2015 Sep;53(9):3039-41. doi: 10.1128/JCM.01457-15. Epub 2015 Jul 1.
The impact of the HCV genotype 1b core amino acid (aa) 70 mutant on the cumulative rate of hepatocellular carcinoma following eradication of HCV RNA by antiviral therapy was investigated with the Q-Invader assay. Multivariate analysis based on 649 patients indicated that a core aa70 Q-Invader mutant level ≥20% is a predictor of hepatocellular carcinoma.
采用Q-Invader检测法研究了丙型肝炎病毒(HCV)1b基因型核心氨基酸(aa)70突变体对经抗病毒治疗根除HCV RNA后肝细胞癌累积发生率的影响。基于649例患者的多变量分析表明,核心aa70 Q-Invader突变体水平≥20%是肝细胞癌的一个预测指标。