通过亲核试剂特异性控制实现串联的选择性铃木-宫浦交叉偶联反应。
Tandem Chemoselective Suzuki-Miyaura Cross-Coupling Enabled by Nucleophile Speciation Control.
机构信息
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL (UK).
出版信息
Angew Chem Int Ed Engl. 2015 Aug 17;54(34):9976-9. doi: 10.1002/anie.201504297. Epub 2015 Jul 1.
PMID:26136166
Abstract
Control of boronic acid speciation is presented as a strategy to achieve nucleophile chemoselectivity in the Suzuki-Miyaura reaction. Combined with simultaneous control of oxidative addition and transmetalation, this enables chemoselective formation of two C-C bonds in a single operation, providing a method for the rapid preparation of highly functionalized carbogenic frameworks.
摘要
控制硼酸的形态被认为是在 Suzuki-Miyaura 反应中实现亲核试剂化学选择性的一种策略。结合同时控制氧化加成和转金属化反应，可以在单个操作中实现两个 C-C 键的化学选择性形成，为快速制备高功能化碳骨架提供了一种方法。
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