一枚硬币的两面：急性肝衰竭中的大规模肝坏死与祖细胞介导的再生
Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure.
作者信息
Weng Hong-Lei, Cai Xiaobo, Yuan Xiaodong, Liebe Roman, Dooley Steven, Li Hai, Wang Tai-Ling
机构信息
Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University Mannheim, Germany.
Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University Mannheim, Germany ; Department of Medicine II, Saarland University Hospital Homburg, Germany.
出版信息
Front Physiol. 2015 Jun 16;6:178. doi: 10.3389/fphys.2015.00178. eCollection 2015.
Massive hepatic necrosis is a key event underlying acute liver failure, a serious clinical syndrome with high mortality. Massive hepatic necrosis in acute liver failure has unique pathophysiological characteristics including extremely rapid parenchymal cell death and removal. On the other hand, massive necrosis rapidly induces the activation of liver progenitor cells, the so-called "second pathway of liver regeneration." The final clinical outcome of acute liver failure depends on whether liver progenitor cell-mediated regeneration can efficiently restore parenchymal mass and function within a short time. This review summarizes the current knowledge regarding massive hepatic necrosis and liver progenitor cell-mediated regeneration in patients with acute liver failure, the two sides of one coin.
大面积肝坏死是急性肝衰竭这一具有高死亡率的严重临床综合征的关键事件。急性肝衰竭中的大面积肝坏死具有独特的病理生理特征，包括实质细胞极其迅速的死亡和清除。另一方面，大面积坏死迅速诱导肝祖细胞活化，即所谓的“肝脏再生第二条途径”。急性肝衰竭的最终临床结局取决于肝祖细胞介导的再生能否在短时间内有效恢复实质细胞量和功能。本综述总结了目前关于急性肝衰竭患者大面积肝坏死和肝祖细胞介导的再生的知识，这是同一枚硬币的两面。
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