Ji Huihui, Dai Dongjun, Wang Yunliang, Jiang Danjie, Zhou Xingyu, Lin Peipei, Ji Xiaosui, Li Jinfeng, Zhang Yuzheng, Yin Honglei, Chen Rongrong, Zhang Lina, Xu Mingqing, Duan Shiwei, Wang Qinwen
Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255300, P.R. China.
Exp Ther Med. 2015 May;9(5):1831-1840. doi: 10.3892/etm.2015.2327. Epub 2015 Mar 3.
Alzheimer's disease (AD) is a common neurodegenerative disorder that can destroy the memory of sufferers and lead to distress for the individual and society. Brain-derived neurotrophic factor () and butyrylcholinesterase () are two genes associated with β-amyloid plaques and neurofibrillary tangles that are two key factors in the pathophysiology of AD. The aim of the current meta-analysis was to evaluate the association between Val66Met (rs6265), C270T (rs2030324) and -K (rs1803274) polymorphisms and AD. A comprehensive meta-analysis was performed using the online database PubMed without a time limitation. A total of 56 articles evaluating 12,563 cases and 12,622 controls were selected for the current meta-analysis. The results showed a moderate association of the C270T polymorphism with the risk of AD in Asians under a dominant model (P=0.03; odds ratio, 1.88; 95% confidence interval, 1.08-3.27). No other significant association was found during the meta-analysis for the other two polymorphisms (P>0.05). The current meta-analysis suggests that C270T is a risk factor for AD in Asians. This meta-analysis has been, to the best of our knowledge, the most comprehensive meta-analysis of Val66Met, C270T and -K to date.
阿尔茨海默病（AD）是一种常见的神经退行性疾病，它会破坏患者的记忆，给个人和社会带来痛苦。脑源性神经营养因子（）和丁酰胆碱酯酶（）是与β-淀粉样斑块和神经原纤维缠结相关的两个基因，而这两者是AD病理生理学中的两个关键因素。本荟萃分析的目的是评估Val66Met（rs6265）、C270T（rs2030324）和-K（rs1803274）基因多态性与AD之间的关联。使用无时间限制的在线数据库PubMed进行了全面的荟萃分析。本荟萃分析共纳入了56篇评估12563例病例和12622例对照的文章。结果显示，在显性模型下，亚洲人中C270T基因多态性与AD风险存在中度关联（P = 0.03；比值比，1.88；95%置信区间，1.08 - 3.27）。在对其他两个多态性的荟萃分析中未发现其他显著关联（P>0.05）。本荟萃分析表明，C270T是亚洲人患AD的一个风险因素。据我们所知，本荟萃分析是迄今为止对Val66Met、C270T和-K最全面的荟萃分析。
