Rudjer Boskovic Institute, Zagreb, Croatia.
Rudjer Boskovic Institute, Zagreb, Croatia.
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110452. doi: 10.1016/j.pnpbp.2021.110452. Epub 2021 Oct 9.
Studies investigating the association between smoking and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have reported inconclusive results, while the studies on the association of smoking status with BDNF C270T polymorphism are missing. We aimed to determine the association of smoking and BDNF Val66Met and C270T genetic variants in control subjects and patients with mental disorders. This study included 3502 Caucasian subjects: 918 healthy controls and 2584 patients with mental disorders (519 individuals with posttraumatic stress disorder (PTSD), 419 patients with depression, 996 patients with schizophrenia, and 650 patients with alcohol dependence). The frequency of the BDNF Val66Met and C270T variants were presented in codominant, dominant and recessive models. BDNF C270T, but not BDNF Val66Met polymorphism, was significantly associated with smoking in all groups, since the presence of the C270T T allele was more frequently found in smokers compared to non-smokers. Significant predictors of smoking were sex, age and BDNF C270T genetic variants. However, after detailed analysis of the separate diagnostic entities, the significant association of BDNF C270T polymorphism was confirmed only in healthy subjects, but not in patients with mental disorders; and was not related to number of cigarettes smoked per day. In patients with alcohol dependence, the severity of smoking was significantly associated with BDNF Val66Met variants. This is a first report of the significant association between the BDNF C270T polymorphism and smoking status in the large groups of Caucasian cases/controls.
研究吸烟与脑源性神经营养因子（BDNF）Val66Met 多态性之间的关系的报告结果并不一致，而关于吸烟状况与 BDNF C270T 多态性之间的关系的研究则缺失。我们旨在确定吸烟与 BDNF Val66Met 和 C270T 遗传变异在对照组和精神障碍患者中的相关性。这项研究包括 3502 名白种人受试者：918 名健康对照者和 2584 名精神障碍患者（519 名创伤后应激障碍（PTSD）患者、419 名抑郁症患者、996 名精神分裂症患者和 650 名酒精依赖患者）。BDNF Val66Met 和 C270T 变体的频率以共显性、显性和隐性模式呈现。BDNF C270T，但不是 BDNF Val66Met 多态性，与所有组中的吸烟显著相关，因为与非吸烟者相比，C270T T 等位基因在吸烟者中更为常见。吸烟的显著预测因子是性别、年龄和 BDNF C270T 遗传变异。然而，在对单独的诊断实体进行详细分析后，仅在健康受试者中证实了 BDNF C270T 多态性与吸烟之间的显著关联，而在精神障碍患者中则没有；并且与每天吸烟的数量无关。在酒精依赖患者中，吸烟的严重程度与 BDNF Val66Met 变异显著相关。这是首次在大型白种人病例/对照群体中报告 BDNF C270T 多态性与吸烟状态之间存在显著关联。
