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一种佐剂全细胞疫苗作为急性白血病缓解后免疫疗法。

An adjuvanted whole cell vaccine as post-remission immunotherapy for acute leukemia.

作者信息

Weinkove Robert, Ancelet Lindsay R, Gibbins John D, Hermans Ian F

机构信息

Malaghan Institute of Medical Research , Wellington, New Zealand.

Malaghan Institute of Medical Research , Wellington, New Zealand ; School of Biological Sciences, Victoria University of Wellington , Wellington, New Zealand.

出版信息

Oncoimmunology. 2015 Jan 22;4(4):e995568. doi: 10.1080/2162402X.2014.995568. eCollection 2015 Apr.

DOI:10.1080/2162402X.2014.995568
PMID:26137409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4485719/
Abstract

Many acute leukemia patients treated with chemotherapy are at high risk of relapse without allogeneic stem cell transplantation, an immunotherapy that is limited by significant toxicity and donor availability. We propose that post-remission vaccination with a simple autologous whole cell vaccine adjuvanted with α-galactosylceramide may be effective to prevent relapse of acute leukemia.

摘要

许多接受化疗的急性白血病患者在没有进行异基因干细胞移植的情况下复发风险很高，而异基因干细胞移植这种免疫疗法受到显著毒性和供体可用性的限制。我们提出，使用佐以α-半乳糖神经酰胺的简单自体全细胞疫苗进行缓解后疫苗接种可能有效预防急性白血病复发。

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An adjuvanted whole cell vaccine as post-remission immunotherapy for acute leukemia.一种佐剂全细胞疫苗作为急性白血病缓解后免疫疗法。
Oncoimmunology. 2015 Jan 22;4(4):e995568. doi: 10.1080/2162402X.2014.995568. eCollection 2015 Apr.
2
Is there a place for immunotherapy with interleukin-2 to prevent relapse after autologous stem cell transplantation for acute leukemia?白细胞介素-2免疫疗法在预防急性白血病自体干细胞移植后复发方面是否有一席之地？
Leuk Lymphoma. 1995 Feb;16(5-6):397-405. doi: 10.3109/10428199509054425.
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Autologous stem cell transplantation versus alternative allogeneic donor transplants in adult acute leukemias.成人急性白血病中自体干细胞移植与替代供体异基因移植的比较
Semin Hematol. 2016 Apr;53(2):103-10. doi: 10.1053/j.seminhematol.2016.01.003. Epub 2016 Jan 19.
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A systematic overview of chemotherapy effects in acute myeloid leukaemia.急性髓系白血病化疗效果的系统综述。
Acta Oncol. 2001;40(2-3):231-52. doi: 10.1080/02841860151116321.
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Treatment of relapsed acute leukemia after allogeneic transplantation: a single center experience.异基因移植后复发急性白血病的治疗：单中心经验
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Allogeneic cell therapy for relapsed leukemia after bone marrow transplantation with donor peripheral blood lymphocytes.采用供体外周血淋巴细胞对骨髓移植后复发白血病进行异基因细胞治疗。
Exp Hematol. 1995 Dec;23(14):1553-62.
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Autologous or allogeneic stem cell transplantation as post-remission therapy in refractory or relapsed acute myeloid leukemia after highly intensive chemotherapy.自体或异基因干细胞移植作为难治性或复发性急性髓系白血病强化疗后缓解期的治疗方法。
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Bone marrow transplantation for acute leukemia: recent advances and comparison with alternative therapies.急性白血病的骨髓移植：最新进展及与其他疗法的比较
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Comparison of intensive chemotherapy, allogeneic or autologous stem cell transplantation as post-remission treatment for adult patients with high-risk acute lymphoblastic leukemia. Results of the PETHEMA ALL-93 trial.强化化疗、异基因或自体干细胞移植作为高危成人急性淋巴细胞白血病缓解后治疗的比较。PETHEMA ALL-93试验结果
Haematologica. 2005 Oct;90(10):1346-56.

本文引用的文献

1
An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment.自体白血病细胞疫苗可预防阿糖胞苷治疗后小鼠急性白血病的复发。
Blood. 2014 Nov 6;124(19):2953-63. doi: 10.1182/blood-2014-04-568956. Epub 2014 Sep 18.
2
Relapse kinetics in acute myeloid leukaemias with MLL translocations or partial tandem duplications within the MLL gene.MLL 易位或 MLL 基因内部分串联重复急性髓系白血病的复发动力学。
Br J Haematol. 2014 Jun;165(5):618-28. doi: 10.1111/bjh.12792. Epub 2014 Feb 24.
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Immunotherapy in acute myeloid leukemia.免疫疗法在急性髓系白血病中的应用。
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Immunotherapeutic strategies for relapse control in acute myeloid leukemia.免疫治疗策略在急性髓系白血病中的复发控制作用。
Blood Rev. 2013 Sep;27(5):209-16. doi: 10.1016/j.blre.2013.06.006. Epub 2013 Jul 18.
5
Generation of tumor antigen-specific T cell lines from pediatric patients with acute lymphoblastic leukemia--implications for immunotherapy.从急性淋巴细胞白血病患儿中生成肿瘤抗原特异性 T 细胞系 - 免疫治疗的意义。
Clin Cancer Res. 2013 Sep 15;19(18):5079-91. doi: 10.1158/1078-0432.CCR-13-0955. Epub 2013 Jul 9.
6
Acute myeloid leukemia: 2013 update on risk-stratification and management.急性髓细胞白血病：2013 年风险分层与治疗策略更新
Am J Hematol. 2013 Apr;88(4):318-27. doi: 10.1002/ajh.23404.
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Acute lymphoblastic leukaemia.急性淋巴细胞白血病。
Lancet. 2013 Jun 1;381(9881):1943-55. doi: 10.1016/S0140-6736(12)62187-4. Epub 2013 Mar 22.
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Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy.慢性淋巴细胞白血病中功能性不变自然杀伤 T 细胞和 CD1d 轴：免疫治疗的意义。
Haematologica. 2013 Mar;98(3):376-84. doi: 10.3324/haematol.2012.072835. Epub 2012 Oct 12.
9
Immunologic consequences of chemotherapy for acute myeloid leukemia.急性髓系白血病化疗的免疫后果
J Pediatr Hematol Oncol. 2013 Jan;35(1):46-53. doi: 10.1097/MPH.0b013e318266c0c8.
10
Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?急性髓系白血病中的调节性 T 细胞：是否到了免疫调节的时候？
Blood. 2011 Nov 10;118(19):5084-95. doi: 10.1182/blood-2011-07-365817. Epub 2011 Aug 31.