Reilly Anne, Kersun Leslie S, Luning Prak Eline, Boyer Jean, McDonald Kenyetta, Jawad Abbas F, Sullivan Kathleen E
Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
J Pediatr Hematol Oncol. 2013 Jan;35(1):46-53. doi: 10.1097/MPH.0b013e318266c0c8.
There are few data characterizing the immunologic consequences of chemotherapy for acute myeloid leukemia (AML) and almost nothing is known about the effects of chemotherapy in a pediatric AML cohort. We identified T-cell subsets, B-cell subsets, and used Enzyme-linked immunosorbent spot analyses to define the function of T cells and B cells in 7 pediatric patients with AML on chemotherapy. The data show that the effects of chemotherapy disproportionately target the B cell and depletion of B cells is associated with impaired responses to the inactivated influenza vaccine. Diminished T-cell numbers were also observed although the magnitude of the effect was less than what was seen for B cells. Furthermore, measures of T-cell function were largely intact. We conclude that humoral immunity is significantly affected by chemotherapy for AML.
关于急性髓系白血病（AML）化疗的免疫后果的数据很少，对于儿科AML队列中化疗的影响几乎一无所知。我们鉴定了T细胞亚群、B细胞亚群，并使用酶联免疫吸附斑点分析来确定7名接受化疗的儿科AML患者中T细胞和B细胞的功能。数据显示，化疗的影响对B细胞的靶向作用不成比例，B细胞的耗竭与对灭活流感疫苗的反应受损有关。虽然观察到T细胞数量减少，但其影响程度小于B细胞。此外，T细胞功能的指标在很大程度上是完整的。我们得出结论，AML化疗显著影响体液免疫。
