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在手性固定相上通过液相色谱法对前列腺素前体对映体进行制备拆分。

Preparative resolution of enantiomers of prostaglandin precursors by liquid chromatography on a chiral stationary phase.

作者信息

Miller L, Bush H

机构信息

Chemical Development Department, G.D. Searle and Co., Skokie, IL 60077.

出版信息

J Chromatogr. 1989 Dec 22;484:337-45. doi: 10.1016/s0021-9673(01)88981-0.

DOI:10.1016/s0021-9673(01)88981-0
PMID:2613792
Abstract

Preparative liquid chromatographic methods were developed for the chiral resolution of two different cyclopentenone precursors of a synthetic prostaglandin. Various solvent combinations of alcohols and alkanes were investigated to determine the method which has the greatest throughput. The effect of particle size on the chiral resolution was also investigated. In addition, the preparative system was automated to allow for unattended operation for up to 10 h.

摘要

已开发出制备型液相色谱方法，用于拆分一种合成前列腺素的两种不同环戊烯酮前体的对映体。研究了醇类和烷烃的各种溶剂组合，以确定通量最大的方法。还研究了粒径对映体拆分的影响。此外，制备系统实现了自动化，可无人值守操作长达10小时。

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