Maayan M L, Volpert E M
Veterans Administration Medical Center, Brooklyn, N.Y. 11209.
J Endocrinol Invest. 1989 Dec;12(11):773-6. doi: 10.1007/BF03350057.
Norepinephrine (NE) failed to increase thyroid hormone release in mice when endogenous TSH secretion had been greatly reduced by a variety of means. This was demonstrated by radioiodine release in mice pretreated with 131I and with thyroxine (T4) or 3,5,3' triiodothyronine (T3). by radioimmunoassay (RIA) in mice pretreated with 131I and T3, and in mice which had been hypophysectomized, or where TSH secretion had been decreased by prolonged administration of exogenous TSH. T4 could not be measured by RIA in mice pretreated with T4.
当通过多种方法使内源性促甲状腺激素(TSH)分泌大幅减少时,去甲肾上腺素(NE)未能增加小鼠甲状腺激素的释放。这在接受过¹³¹I以及甲状腺素(T4)或三碘甲状腺原氨酸(T3)预处理的小鼠的放射性碘释放实验中得到了证实。在接受过¹³¹I和T3预处理的小鼠、垂体切除的小鼠或通过长期给予外源性TSH使TSH分泌减少的小鼠中,通过放射免疫测定法(RIA)也得到了证实。在用T4预处理的小鼠中,无法通过RIA测定T4。