Maayan M L, Debons A F, Krimsky I, Volpert E M, From A, Dawry F, Siclari E
Endocrinology. 1977 Jul;101(1):284-91. doi: 10.1210/endo-101-1-284.
Thyrotropin (TSH), 1 MU/ml and N6, O2'-dibutyryl adenosine 3',5-cyclic monophosphoric acid (dbcAMP) greatly enhanced the release of thyroxine (T4) and triiodothyronine (T3) from mouse thyroids incubated in vitro. L-Epinephrine (E) and L-norepinephrine (NE) strongly inhibited the TSH and dbcAMP-stimulated release of thyroid hormones; L-isoproterenol (IPNE) exerted a relatively weak inhibition. The inhibition by catecholamines was prevented by the alpha-adrenergic blocker, phentolamine; L-propranolol, a beta-adrenergic blocker, had no effect on the inhibition. The TSH-induced release of thyroid hormones was not affected by adrenergic blockers. Epinephrine did not affect the increase in thyroidal cAMP content induced by TSH. These results indicate that catecholamines act by way of an alpha-adrenergic receptor to suppress TSH-stimulated release of thyroid hormones at a point beyond cAMP formation.
促甲状腺激素（TSH），1 MU/ml和N6，O2'-二丁酰腺苷3'，5-环一磷酸（dbcAMP）极大地增强了体外培养的小鼠甲状腺中甲状腺素（T4）和三碘甲状腺原氨酸（T3）的释放。L-肾上腺素（E）和L-去甲肾上腺素（NE）强烈抑制TSH和dbcAMP刺激的甲状腺激素释放；L-异丙肾上腺素（IPNE）的抑制作用相对较弱。α-肾上腺素能阻滞剂酚妥拉明可阻止儿茶酚胺的抑制作用；β-肾上腺素能阻滞剂L-普萘洛尔对这种抑制作用无影响。TSH诱导的甲状腺激素释放不受肾上腺素能阻滞剂的影响。肾上腺素不影响TSH诱导的甲状腺cAMP含量增加。这些结果表明，儿茶酚胺通过α-肾上腺素能受体在cAMP形成之后的某个点抑制TSH刺激的甲状腺激素释放。
