Haave N C, Innis S M
Department of Paediatrics, University of British Columbia, Vancouver, Canada.
J Dev Physiol. 1989 Jul;12(1):11-4.
Rats fed a non-absorbable bile acid binding resin (cholestyramine) throughout gestation had decreased activities of adipose tissue lipoprotein lipase (LPL), hepatic triacylglycerol lipase and a heparin-releasable placental lipase distinct from LPL, when assayed at near-term gestation. The fetal plasma and liver triacylglycerol concentrations were not altered. The fetal liver total lipid and plasma triacylglycerol, however, had reduced levels of n-6 and n-3 series fatty acids, suggesting decreased availability of maternal dietary-derived essential fatty acids. These studies suggest that cholestyramine feeding may alter triacylglycerol flux and the quantity or type of maternal fatty acids available for placental transfer. The resin has application for in vivo study of the effects of maternal lipid transfer on the regulation of fetal hepatic lipid synthesis.
在整个妊娠期喂食不可吸收的胆汁酸结合树脂（消胆胺）的大鼠，在妊娠晚期进行检测时，其脂肪组织脂蛋白脂肪酶（LPL）、肝脏三酰甘油脂肪酶以及一种不同于LPL的可被肝素释放的胎盘脂肪酶的活性降低。胎儿血浆和肝脏中的三酰甘油浓度未发生改变。然而，胎儿肝脏中的总脂质以及血浆三酰甘油中n-6和n-3系列脂肪酸的水平降低，这表明母体饮食来源的必需脂肪酸的可利用性降低。这些研究表明，喂食消胆胺可能会改变三酰甘油的通量以及可用于胎盘转运的母体脂肪酸的数量或类型。该树脂可用于体内研究母体脂质转运对胎儿肝脏脂质合成调节的影响。
