Haave N C, Innis S M
Department of Paediatrics, University of British Columbia, Vancouver, Canada.
J Dev Physiol. 1988 Jun;10(3):247-55.
Late gestation foetus from rats fed a non-absorbable bile acid binding resin (cholestyramine) have increased hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. This was due to increased unphosphorylated (active) as well as total reductase and was accompanied by higher fatty acid synthetase activity. No increase in foetal hepatic cystathionase or tyrosine aminotransferase activity, or changes in plasma insulin, corticosterone or thyroxine were found. The studies demonstrate that foetal hepatic cholesterol metabolism is sensitive to drug-induced perturbation of maternal lipoprotein metabolism. The data suggest induction of foetal cholesterol and fatty acid synthesis by a specific mechanism not involving generalized hormone-induction of hepatic enzyme systems. Cholestyramine appears to have application for in vivo study of the regulation of foetal cholesterologenesis and its coordination to maternal and foetal steroid requirements.
给妊娠后期的大鼠喂食一种不可吸收的胆汁酸结合树脂（消胆胺），其胎儿肝脏的3-羟基-3-甲基戊二酰辅酶A还原酶活性增加。这是由于未磷酸化（活性）的还原酶以及总还原酶增加所致，同时伴有较高的脂肪酸合成酶活性。未发现胎儿肝脏胱硫醚酶或酪氨酸转氨酶活性增加，也未发现血浆胰岛素、皮质酮或甲状腺素发生变化。这些研究表明，胎儿肝脏胆固醇代谢对药物诱导的母体脂蛋白代谢紊乱敏感。数据表明，胎儿胆固醇和脂肪酸合成是通过一种不涉及肝脏酶系统普遍激素诱导的特定机制诱导的。消胆胺似乎可用于胎儿胆固醇生成调节及其与母体和胎儿类固醇需求协调的体内研究。
