Read Gaia, Ingersoll Karen S
Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, 310 Old Ivy Way, Suite 102, Charlottesville, VA, 22903, USA.
AIDS Behav. 2016 Mar;20(3):633-45. doi: 10.1007/s10461-015-1119-6.
This is a secondary analysis of data from a randomized trial of dually-focused interventions for nonadherent HIV patients with cocaine use disorders (Ingersoll et al. in Drug Alcohol Depend 116(1-3):177-187, 2011). We examined the relationships among baseline demographic, psychological, psychiatric, and behavioral characteristics and 6-months post-study ART adherence, log viral load (VL), ASI Drug Composite Score, and days using cocaine. We used the SAS GLMSELECT procedure to build multivariate models of each post-study outcome. Post-study ART adherence was related to 2 psychological variables; while logVL was related to 2 drug-related behaviors. ASI Drug Composite score was related to 2 psychiatric disorders, 1 demographic, and 1 psychological variable; in contrast, days using cocaine related to 1 behavioral and 3 psychological variables. Analyses show clear, robust relationships among behavioral, psychological and psychiatric diagnosis factors with post-study ART adherence and cocaine use outcomes. Future ART adherence interventions for cocaine users should consider tailoring to these patient characteristics.
这是一项对非依从性HIV患者合并可卡因使用障碍的双重聚焦干预随机试验数据的二次分析（英格索尔等人，《药物与酒精依赖》，2011年，第116卷第1 - 3期，第177 - 187页）。我们研究了基线人口统计学、心理、精神和行为特征与研究后6个月的抗逆转录病毒治疗（ART）依从性、对数病毒载量（VL）、成瘾严重程度指数（ASI）药物综合评分以及使用可卡因天数之间的关系。我们使用SAS GLMSELECT程序建立每个研究后结局的多变量模型。研究后ART依从性与2个心理变量有关；而对数病毒载量与2种与药物相关的行为有关。ASI药物综合评分与2种精神障碍、1个人口统计学变量和1个心理变量有关；相比之下，使用可卡因天数与1种行为和3个心理变量有关。分析表明，行为、心理和精神诊断因素与研究后ART依从性和可卡因使用结局之间存在明确、稳健的关系。未来针对可卡因使用者的ART依从性干预措施应考虑根据这些患者特征进行调整。
