Division of Advisory Committee and Consultant Management, Office of Executive Programs, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, WO31-2417, Silver Spring, MD 20993-0002, USA.
Department of Pharmacotherapeutics and Clinical Research, University of South Florida College of Pharmacy, 12901 Bruce B. Downs Boulevard, MDC 30, Tampa, FL 33612, USA.
Int J Antimicrob Agents. 2015 Sep;46(3):290-6. doi: 10.1016/j.ijantimicag.2015.05.007. Epub 2015 Jun 19.
Drug-resistant Neisseria gonorrhoeae has become a global health concern that requires immediate attention. Due to increasing resistance to cephalosporins, pursuing novel alternatives for treating N. gonorrhoeae infections is paramount. Whilst new drug development is often cumbersome, reviving antiquated antibiotic agents for treatment of modern infections has become prevalent in clinical practice. Fosfomycin exhibits bactericidal activity through a unique mechanism of action, and a variety of organisms including N. gonorrhoeae are susceptible. In vitro studies have demonstrated that fosfomycin can retain activity against ceftriaxone-resistant N. gonorrhoeae; however, it remains unclear whether there is synergy between fosfomycin and other antibiotics. Clinical investigations evaluating fosfomycin for the treatment of N. gonorrhoeae infections are confounded by methodological limitations, none the less they do provide some perspective on its potential role in therapy. Future studies are needed to establish a safe, convenient and effective fosfomycin regimen for treating N. gonorrhoeae infections.
耐头孢菌素淋病奈瑟菌已成为全球关注的健康问题，需要立即引起重视。由于对头孢菌素的耐药性不断增加，因此迫切需要寻找治疗淋病奈瑟菌感染的新方法。虽然新药的开发通常很繁琐，但在临床实践中，重新使用陈旧的抗生素来治疗现代感染已变得很普遍。磷霉素通过独特的作用机制发挥杀菌作用，包括淋病奈瑟菌在内的多种病原体对其敏感。体外研究表明，磷霉素对头孢曲松耐药的淋病奈瑟菌仍具有活性；然而，目前尚不清楚磷霉素与其他抗生素之间是否存在协同作用。由于方法学上的局限性，评估磷霉素治疗淋病奈瑟菌感染的临床研究受到了混淆；尽管如此，它们确实为其在治疗中的潜在作用提供了一些参考。需要进一步的研究来确定一种安全、方便、有效的磷霉素方案，以治疗淋病奈瑟菌感染。
