Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai, China.
J Med Virol. 2016 Feb;88(2):304-11. doi: 10.1002/jmv.24321. Epub 2015 Jul 17.
Kaposi's sarcoma-associated herpesvirus (KSHV) may be transmitted via sexual contacts, but limited information is available on KSHV infection status among sexually transmitted infection (STI) patients in China. The main objective of the present study was to determine the KSHV seroprevalence and its risk factors among male STI patients. A cross-sectional survey was conducted in three prefectures of Anhui province, China, between June and September 2013. A total of 1,600 male patients who visited an STI clinic were invited, and 1,372 participated in the study. Data were abstracted from the medical records for all the patients. Blood samples were collected and tested for antibodies to KSHV, HIV, HCV, and syphilis. Factors associated with KSHV seropositivity were examined using multivariable logistic regression analysis. The overall prevalence of KSHV, HIV, HCV, and syphilis was 13.3%, 0.7%, 0.6%, and 12.5%, respectively. After adjusting for potential confounders, KSHV infection was significantly associated with ever having anal sex with men (19 out of 30 males, OR: 8.64, 95%CI: 1.92-38.79) and HIV infection (six out of nine HIV-positive individuals, OR: 8.39, 95%CI: 1.80-39.04). There were no significant associations of KSHV infection with drug use, heterosexual sex behaviors, syphilis, and HCV. Our finding has shown that a relatively moderate prevalence of KSHV was found among male STI patients. While an increased risk for KSHV infection was observed among participants with homosexual contacts. Routine KSHV testing is recommended for male individuals attending STI clinics.
卡波氏肉瘤相关疱疹病毒（KSHV）可能通过性接触传播，但在中国性传播感染（STI）患者中，有关 KSHV 感染状况的信息有限。本研究的主要目的是确定男性 STI 患者中的 KSHV 血清流行率及其危险因素。2013 年 6 月至 9 月，在中国安徽省的三个地区进行了一项横断面调查。邀请了 1600 名男性患者到 STI 诊所就诊，其中 1372 名患者参加了研究。所有患者的病历数据均从病历中提取。采集血液样本并检测 KSHV、HIV、HCV 和梅毒抗体。使用多变量逻辑回归分析检查与 KSHV 血清阳性相关的因素。KSHV、HIV、HCV 和梅毒的总体流行率分别为 13.3%、0.7%、0.6%和 12.5%。调整潜在混杂因素后，KSHV 感染与既往与男性发生肛交（30 名男性中有 19 人，OR：8.64，95%CI：1.92-38.79）和 HIV 感染（9 名 HIV 阳性个体中有 6 人，OR：8.39，95%CI：1.80-39.04）显著相关。KSHV 感染与吸毒、异性性行为、梅毒和 HCV 无显著关联。我们的研究结果表明，男性 STI 患者中 KSHV 的流行率相对较高。而与同性恋接触者相比，KSHV 感染的风险增加。建议在 STI 诊所就诊的男性个体进行常规 KSHV 检测。
