美国南部男男性行为者中卡波西肉瘤相关疱疹病毒感染的流行率、发生率和预测因素。
Prevalence, Incidence, and Predictors of Kaposi Sarcoma-Associated Herpesvirus Infection Among Young Men Who Have Sex With Men in the Southern United States.
机构信息
Institute of Behavioral Research, Texas Christian University, Fort Worth.
Division of Infectious Diseases and Geographic Medicine, Department of Internal Medicine, University of Texas Southwestern.
出版信息
J Infect Dis. 2024 May 15;229(5):1387-1392. doi: 10.1093/infdis/jiad384.
Abstract
Kaposi sarcoma (KS) continues to cause substantial morbidity and mortality in populations at risk in the southern United States. Utilizing biospecimens from the Houston site of the Young Men's Affiliate Project, 351 men who have sex with men had blood tested for KS-associated herpesvirus (KSHV) IgG. Seroprevalence, seroconversion between time points, and demographic and clinical correlates were measured. KSHV prevalence was 36.7% and incidence was 8.9 per 100 person-years. Furthermore, prevalence and incidence were higher among Black individuals, people living with HIV, and those with a history of syphilis. Further research on KSHV risk may improve health disparities in KS diagnosis and outcomes.
摘要
卡波西肉瘤（KS）在美国南部的高危人群中仍会导致大量的发病率和死亡率。利用来自休斯顿年轻人附属项目（Young Men's Affiliate Project）的生物标本，对 351 名男男性行为者进行了血液检测，以检测与卡波西肉瘤相关的疱疹病毒（KSHV）IgG。检测了血清阳性率、时间点之间的血清转化率以及人口统计学和临床相关因素。结果显示，KSHV 的流行率为 36.7%，发病率为每 100 人年 8.9 例。此外，黑人、艾滋病毒感染者以及梅毒病史者的 KSHV 患病率和发病率更高。进一步研究 KSHV 风险因素可能会改善 KS 诊断和结果方面的健康差异。
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