[人体体外循环期间尿前列腺素的变化]
[Changes in urinary prostaglandins during cardiopulmonary bypass in man].
作者信息
Arima T, Ohata M, Matsuura M, Nakamura S, Matsumoto I, Hori T
出版信息
Masui. 1989 Jul;38(7):908-12.
We measured urinary and plasma levels of thromboxane B2 (TXB2), 6-keto PGF1 alpha and urinary NAG during cardiopulmonary bypass (CPB) and studied their clinical significance. Subjects studied were 10 patients undergoing coronary artery bypass graft. Urinary and plasma levels of TXB2 and 6-keto PGF1 alpha increased during CPB. However, predictive plasma levels of TXB2 and 6-keto PGF1 alpha, calculated by urinary excretion, were higher than actual plasma levels. This result suggests that the kidney produces TXA2 and PGI2. Significant correlation (r = 0.87, P less than 0.01) was observed between NAG and TXB2 during CPB. The results suggest that TXA2 impairs the function of the renal urinary tubules.
我们在体外循环（CPB）期间测量了血栓素B2（TXB2）、6-酮-前列腺素F1α的尿液和血浆水平以及尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG），并研究了它们的临床意义。研究对象为10例接受冠状动脉旁路移植术的患者。CPB期间TXB2和6-酮-前列腺素F1α的尿液和血浆水平升高。然而，通过尿排泄计算得出的TXB2和6-酮-前列腺素F1α的预测血浆水平高于实际血浆水平。这一结果表明肾脏产生血栓素A2（TXA2）和前列环素（PGI2）。CPB期间NAG与TXB2之间存在显著相关性（r = 0.87，P < 0.01）。结果表明TXA2损害肾肾小管功能。
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