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伴有和不伴有幻听的I型双相情感障碍患者的特征。

Characteristics of people with bipolar disorder I with and without auditory verbal hallucinations.

作者信息

Javier Aster, Jaworska Natalia, Fiedorowicz Jess, Magnotta Vincent, Richards Jenny G, Barsotti Ercole John, Wemmie John A

机构信息

University of Ottawa Institute of Mental Health Research, Ottawa, Canada.

Department of Neuroscience, Carleton University, Ottawa, Canada.

出版信息

Int J Bipolar Disord. 2025 Feb 14;13(1):4. doi: 10.1186/s40345-025-00369-8.

Abstract

BACKGROUND

Approximately half of people with bipolar disorder type I (BD-I) report the presence of psychotic symptoms at least at some point during their illness. Previous data suggest that more than 20% of people with BD-I report the presence of auditory verbal hallucinations (AVHs), or "voice-hearing" in particular. While work in other disorders with psychotic features (e.g., schizophrenia) indicates that the presence vs. absence of AVHs is associated with poorer clinical outcomes, little is known about their effects on clinical and socioeconomic features in BD-I.

METHODS

We investigated whether people with BD-I (N = 119) with AVHs (n = 36) and without AVHs (n = 83) in their lifetime differ in terms of demographic features and clinical measures. Relations with AVHs and other positive symptoms were explored.

RESULTS

People with BD-I and AVHs vs. without AVHs had higher manic and positive symptom scores (i.e., higher scores on the hallucinations, delusions, and bizarre behavior subscales). Further, a greater proportion of those with vs. without AVHs reported lower subjective socioeconomic status and tended to have higher rates of unemployment, thus, speaking to the longer-term consequences of AVH presence.

CONCLUSION

Our findings suggest that people with BD-I with AVHs exhibit more severe psychotic features and manic symptoms compared to those without. This might be associated with more socioeconomic hardship. More in-depth characterization of people with BD-I with/without AVHs is needed to fully understand this subgroup's unique challenges and needs.

LIMITATIONS

The modest sample size of the AVH group and a study population with low racial diversity/representation may limit generalizability.

摘要

背景

大约一半的I型双相情感障碍(BD-I)患者报告在其病程中的至少某些时候存在精神病性症状。先前的数据表明,超过20%的BD-I患者报告存在幻听(AVH),特别是“听到声音”。虽然在其他具有精神病性特征的疾病(如精神分裂症)中的研究表明,AVH的存在与否与较差的临床结局相关,但关于其对BD-I患者的临床和社会经济特征的影响却知之甚少。

方法

我们调查了一生中患有AVH(n = 36)和未患有AVH(n = 83)的BD-I患者(N = 119)在人口统计学特征和临床指标方面是否存在差异。探讨了与AVH及其他阳性症状的关系。

结果

患有AVH的BD-I患者与未患有AVH的患者相比,具有更高的躁狂和阳性症状评分(即幻觉、妄想和怪异行为子量表得分更高)。此外,与未患有AVH的患者相比,患有AVH的患者中有更大比例报告主观社会经济地位较低,且失业率往往更高,因此,这说明了AVH存在的长期后果。

结论

我们的研究结果表明,与未患有AVH的BD-I患者相比,患有AVH的患者表现出更严重的精神病性特征和躁狂症状。这可能与更多的社会经济困难有关。需要对患有/未患有AVH的BD-I患者进行更深入的特征描述,以充分了解该亚组的独特挑战和需求。

局限性

AVH组样本量较小以及研究人群的种族多样性/代表性较低可能会限制研究结果的普遍性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cdc/11828762/db36729e40bd/40345_2025_369_Fig1_HTML.jpg

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